Zwitterionic betaine-cholesterol system: Effects of sonication duration and aging on vesicles stability

R. Alenaizi, Shahidan Radiman, Irman Abdul Rahman, Faizal K.P. Kunchi Mohamed

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nanovesicle structures are an important class of nanoparticle self-assembly offering potential drug delivery applications depending on vesicle shape, size, and stability. The influence of the sonication time and aging effects on size distribution and stability of the vesicles formed in aqueous mixtures of the Zwitterionic surfactant betaine and cholesterol was studied using ternary phase diagrams, negative-staining transmission electron microscopy, and dynamic light scattering. The vast majority of our results reveal assembly of vesicles displaying spherical morphology with diameters varying between 42 and 179. nm during the 42 days of aging period at room temperature. Furthermore, analysis of vesicle structure and conformation following sonication indicate conservation of structural stability without using any stabilizing additives.

Original languageEnglish
Pages (from-to)662-669
Number of pages8
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume482
DOIs
Publication statusPublished - 5 Oct 2015

Fingerprint

Betaines
Betaine
betaines
Sonication
Cholesterol
cholesterol
Aging of materials
structural stability
staining
self assembly
conservation
delivery
drugs
light scattering
assembly
surfactants
phase diagrams
Dynamic light scattering
Drug delivery
Surface-Active Agents

Keywords

  • Cholesterol
  • Dynamic light scattering
  • Negative-staining TEM
  • Ternary phase diagram
  • Vesicles
  • Zwitterionic surfactant

ASJC Scopus subject areas

  • Colloid and Surface Chemistry

Cite this

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abstract = "Nanovesicle structures are an important class of nanoparticle self-assembly offering potential drug delivery applications depending on vesicle shape, size, and stability. The influence of the sonication time and aging effects on size distribution and stability of the vesicles formed in aqueous mixtures of the Zwitterionic surfactant betaine and cholesterol was studied using ternary phase diagrams, negative-staining transmission electron microscopy, and dynamic light scattering. The vast majority of our results reveal assembly of vesicles displaying spherical morphology with diameters varying between 42 and 179. nm during the 42 days of aging period at room temperature. Furthermore, analysis of vesicle structure and conformation following sonication indicate conservation of structural stability without using any stabilizing additives.",
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AU - Alenaizi, R.

AU - Radiman, Shahidan

AU - Abdul Rahman, Irman

AU - K.P. Kunchi Mohamed, Faizal

PY - 2015/10/5

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AB - Nanovesicle structures are an important class of nanoparticle self-assembly offering potential drug delivery applications depending on vesicle shape, size, and stability. The influence of the sonication time and aging effects on size distribution and stability of the vesicles formed in aqueous mixtures of the Zwitterionic surfactant betaine and cholesterol was studied using ternary phase diagrams, negative-staining transmission electron microscopy, and dynamic light scattering. The vast majority of our results reveal assembly of vesicles displaying spherical morphology with diameters varying between 42 and 179. nm during the 42 days of aging period at room temperature. Furthermore, analysis of vesicle structure and conformation following sonication indicate conservation of structural stability without using any stabilizing additives.

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