Zingiber zerumbet rhizomes extract exhibits faster open wound healing in rats

Asmah Hamid, Chong Pek Lian, Nur Hafza Salleh Hudin, Ahmad Rohi Ghazali, Nurul Farhana Jufri

Research output: Contribution to journalArticle

Abstract

Background: Zingiber zerumbet rhizome ethyl acetate extract (ZZRE) has the potential to be developed as a wound-healing agent with its profound anti-inflammatory property. Objective: This study was conducted to evaluate the wound healing effects of 5% ZZRE on open wound in rats. Materials and Methods: Wistar rats (n = 90) were divided into three groups, negative control (treated with PBS), positive control (treated with solcoseryl gel), and 5% ethyl acetate extract of Z. zerumbet, respectively. Wounds were induced on the rat's dorsal surface on day 0. Measurements of wound closure, total protein, uronic acid, hexosamine, cathepsin B, hydroxyproline, and histological observations were conducted on the wound tissues. Results: ZZRE-treated group showed increment in wound closure, protein, and hydroxyproline level. The uronic acid and hexosamine levels of ZZRE-treated wounds significantly increased on the 3rd day (P < 0.05). Histological observations demonstrated formation of granulation tissue was faster and denser in ZZRE-treated group. Conclusion: ZZRE enhances open wound healing in rats and has potential to be developed as a healing agent in the future.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalPharmacognosy Research
Volume10
Issue number4
DOIs
Publication statusPublished - 1 Oct 2018

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Rhizome
Wound Healing
Wounds and Injuries
Uronic Acids
Hexosamines
Hydroxyproline
Actihaemyl
Cathepsin B
Granulation Tissue
ethyl acetate
Wistar Rats
Proteins
Anti-Inflammatory Agents
Gels
Control Groups

Keywords

  • Anti-inflammatory
  • extract
  • proteins
  • rhizomes
  • wound healing
  • Zingiber zerumbet

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Zingiber zerumbet rhizomes extract exhibits faster open wound healing in rats. / Hamid, Asmah; Lian, Chong Pek; Hudin, Nur Hafza Salleh; Ghazali, Ahmad Rohi; Jufri, Nurul Farhana.

In: Pharmacognosy Research, Vol. 10, No. 4, 01.10.2018, p. 354-360.

Research output: Contribution to journalArticle

Hamid, Asmah ; Lian, Chong Pek ; Hudin, Nur Hafza Salleh ; Ghazali, Ahmad Rohi ; Jufri, Nurul Farhana. / Zingiber zerumbet rhizomes extract exhibits faster open wound healing in rats. In: Pharmacognosy Research. 2018 ; Vol. 10, No. 4. pp. 354-360.
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