Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis

Lana Pepdjonovic, Guan Hee Tan, Sean Huang, Sarah Mann, Mark Frydenberg, Daniel Moon, Uri Hanegbi, Adam Landau, Ross Snow, Jeremy Grummet

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To determine the rate of hospital admissions for infection after transperineal biopsy of prostate (TPB) with single-dose cephazolin prophylaxis using a prospective database. Method: Between April 2013 and February 2016, 577 patients undergoing TPB had 2 g of cephazolin given intravenously at induction of anaesthesia. Data collected from these patients included age, PSA, prostate volume, number of cores taken and post-operative complications. Results: No patients were readmitted to hospital with infection post-TPB. Seven patients developed acute urinary retention, and one patient developed clinical prostatitis that was treated with oral antibiotics in the community. Conclusion: It is safe to use single-dose cephazolin only as antibiotic prophylaxis prior to TPB, negating the need for quinolones. This study supports Australia’s current Therapeutic Guidelines recommendation for TPB prophylaxis and the existing evidence that sepsis post-TPB is a rare complication. Whether any antibiotic prophylaxis is needed at all for TPB is the subject of a future study.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalWorld Journal of Urology
DOIs
Publication statusAccepted/In press - 16 Dec 2016

Fingerprint

Cefazolin
Cross Infection
Prostate
Biopsy
Antibiotic Prophylaxis
Prostatitis
Urinary Retention
Quinolones
Sepsis
Anesthesia
Databases
Guidelines
Anti-Bacterial Agents

Keywords

  • Antibiotic prophylaxis
  • Cephazolin
  • Prostate
  • Transperineal biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis. / Pepdjonovic, Lana; Tan, Guan Hee; Huang, Sean; Mann, Sarah; Frydenberg, Mark; Moon, Daniel; Hanegbi, Uri; Landau, Adam; Snow, Ross; Grummet, Jeremy.

In: World Journal of Urology, 16.12.2016, p. 1-5.

Research output: Contribution to journalArticle

Pepdjonovic, L, Tan, GH, Huang, S, Mann, S, Frydenberg, M, Moon, D, Hanegbi, U, Landau, A, Snow, R & Grummet, J 2016, 'Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis', World Journal of Urology, pp. 1-5. https://doi.org/10.1007/s00345-016-1985-1
Pepdjonovic, Lana ; Tan, Guan Hee ; Huang, Sean ; Mann, Sarah ; Frydenberg, Mark ; Moon, Daniel ; Hanegbi, Uri ; Landau, Adam ; Snow, Ross ; Grummet, Jeremy. / Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis. In: World Journal of Urology. 2016 ; pp. 1-5.
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