Xanthorrhizol

A review of its pharmacological activities and anticancer properties

Seok Fang Oon, Meenakshii Nallappan, Thiam Tsui Tee, Shamarina Shohaimi, Nur Kartinee Kassim, Mohd Shazrul Fazry Sa`Ariwijaya, Yew Hoong Cheah

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT's pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT's pharmacological role in drug discovery, thus suggesting areas where further research is required.

Original languageEnglish
Article number100
JournalCancer Cell International
Volume15
Issue number1
DOIs
Publication statusPublished - 21 Oct 2015

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Drug Discovery
Pharmacology
Literature
Curcuma
Poisons
Biological Products
Research
Hypoglycemic Agents
Antihypertensive Agents
Estrogens
Anti-Inflammatory Agents
Antioxidants
Pharmaceutical Preparations
xanthorrhizol
Therapeutics

Keywords

  • Anticancer
  • Curcuma xanthorrhiza Roxb.
  • Pharmacological
  • Xanthorrhizol

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Genetics

Cite this

Xanthorrhizol : A review of its pharmacological activities and anticancer properties. / Oon, Seok Fang; Nallappan, Meenakshii; Tee, Thiam Tsui; Shohaimi, Shamarina; Kassim, Nur Kartinee; Sa`Ariwijaya, Mohd Shazrul Fazry; Cheah, Yew Hoong.

In: Cancer Cell International, Vol. 15, No. 1, 100, 21.10.2015.

Research output: Contribution to journalReview article

Oon, Seok Fang ; Nallappan, Meenakshii ; Tee, Thiam Tsui ; Shohaimi, Shamarina ; Kassim, Nur Kartinee ; Sa`Ariwijaya, Mohd Shazrul Fazry ; Cheah, Yew Hoong. / Xanthorrhizol : A review of its pharmacological activities and anticancer properties. In: Cancer Cell International. 2015 ; Vol. 15, No. 1.
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