Work disability in a multi-ethnic Malaysian systemic lupus erythematosus cohort

A cross-sectional study

Fakhriah Abu Bakar, Syahrul Sazliyana Shaharir, Rozita Mohd, Lydia Kamaruzaman, Mohd Shahrir Mohamed Said

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Abstract

Aim: To determine the prevalence of work disability (WD) among patients with systemic lupus erythematosus (SLE) and its associated factors. Method: This was a cross-sectional study involving SLE patients aged 18-56 years from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Employment history was obtained from clinical interviews. WD was defined as unemployment, interruption of employment or premature cessation of employment due to SLE at any time after the diagnosis. SLE disease characteristics, presence of organ damage and Safety of Estrogens in Lupus Erythematosus National Assessment—SLE Disease Activity Index (SLEDAI) flare index were determined from the medical records. Self-reported quality of life (QoL) was performed using the Medical Outcomes Study Short Form-36 (SF-36). Demographic factors, disease characteristics, and QoL were compared between patients with and without WD using statistical analyses. Results: A total of 215 patients were recruited and the majority were Malay (60.5%), followed by Chinese (33.5%), Indian (4.5%) and others (n = 4, 1.9%). The prevalence of WD was 43.2% (n = 93) with 22.3% (n = 48) patients were unemployed at the time of study. Over half the patients with WD (n = 51, 54.8%) had onset of disability at <5 years from diagnosis. Patients with WD had significantly lower health-related QoL. The independent factors associated with WD were SLEDAI score at diagnosis, frequency of flare, Systemic Lupus International Collaborating Clinics score, being married, had lower education and lupus nephritis. Conclusion: We found a high rate of WD in patients with SLE and it was significantly associated with SLE-related factors, in particular higher disease activity, presence of renal involvement and organ damage.

Original languageEnglish
JournalInternational Journal of Rheumatic Diseases
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Systemic Lupus Erythematosus
Cross-Sectional Studies
Quality of Life
Lupus Nephritis
Time and Motion Studies
Unemployment
Malaysia
Medical Records
Estrogens
Demography
Outcome Assessment (Health Care)
Interviews
Kidney
Safety
Education

Keywords

  • disability
  • lupus
  • nephritis
  • quality of life
  • work

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "Work disability in a multi-ethnic Malaysian systemic lupus erythematosus cohort: A cross-sectional study",
abstract = "Aim: To determine the prevalence of work disability (WD) among patients with systemic lupus erythematosus (SLE) and its associated factors. Method: This was a cross-sectional study involving SLE patients aged 18-56 years from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Employment history was obtained from clinical interviews. WD was defined as unemployment, interruption of employment or premature cessation of employment due to SLE at any time after the diagnosis. SLE disease characteristics, presence of organ damage and Safety of Estrogens in Lupus Erythematosus National Assessment—SLE Disease Activity Index (SLEDAI) flare index were determined from the medical records. Self-reported quality of life (QoL) was performed using the Medical Outcomes Study Short Form-36 (SF-36). Demographic factors, disease characteristics, and QoL were compared between patients with and without WD using statistical analyses. Results: A total of 215 patients were recruited and the majority were Malay (60.5{\%}), followed by Chinese (33.5{\%}), Indian (4.5{\%}) and others (n = 4, 1.9{\%}). The prevalence of WD was 43.2{\%} (n = 93) with 22.3{\%} (n = 48) patients were unemployed at the time of study. Over half the patients with WD (n = 51, 54.8{\%}) had onset of disability at <5 years from diagnosis. Patients with WD had significantly lower health-related QoL. The independent factors associated with WD were SLEDAI score at diagnosis, frequency of flare, Systemic Lupus International Collaborating Clinics score, being married, had lower education and lupus nephritis. Conclusion: We found a high rate of WD in patients with SLE and it was significantly associated with SLE-related factors, in particular higher disease activity, presence of renal involvement and organ damage.",
keywords = "disability, lupus, nephritis, quality of life, work",
author = "{Abu Bakar}, Fakhriah and Shaharir, {Syahrul Sazliyana} and Rozita Mohd and Lydia Kamaruzaman and {Mohamed Said}, {Mohd Shahrir}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/1756-185X.13572",
language = "English",
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T1 - Work disability in a multi-ethnic Malaysian systemic lupus erythematosus cohort

T2 - A cross-sectional study

AU - Abu Bakar, Fakhriah

AU - Shaharir, Syahrul Sazliyana

AU - Mohd, Rozita

AU - Kamaruzaman, Lydia

AU - Mohamed Said, Mohd Shahrir

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: To determine the prevalence of work disability (WD) among patients with systemic lupus erythematosus (SLE) and its associated factors. Method: This was a cross-sectional study involving SLE patients aged 18-56 years from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Employment history was obtained from clinical interviews. WD was defined as unemployment, interruption of employment or premature cessation of employment due to SLE at any time after the diagnosis. SLE disease characteristics, presence of organ damage and Safety of Estrogens in Lupus Erythematosus National Assessment—SLE Disease Activity Index (SLEDAI) flare index were determined from the medical records. Self-reported quality of life (QoL) was performed using the Medical Outcomes Study Short Form-36 (SF-36). Demographic factors, disease characteristics, and QoL were compared between patients with and without WD using statistical analyses. Results: A total of 215 patients were recruited and the majority were Malay (60.5%), followed by Chinese (33.5%), Indian (4.5%) and others (n = 4, 1.9%). The prevalence of WD was 43.2% (n = 93) with 22.3% (n = 48) patients were unemployed at the time of study. Over half the patients with WD (n = 51, 54.8%) had onset of disability at <5 years from diagnosis. Patients with WD had significantly lower health-related QoL. The independent factors associated with WD were SLEDAI score at diagnosis, frequency of flare, Systemic Lupus International Collaborating Clinics score, being married, had lower education and lupus nephritis. Conclusion: We found a high rate of WD in patients with SLE and it was significantly associated with SLE-related factors, in particular higher disease activity, presence of renal involvement and organ damage.

AB - Aim: To determine the prevalence of work disability (WD) among patients with systemic lupus erythematosus (SLE) and its associated factors. Method: This was a cross-sectional study involving SLE patients aged 18-56 years from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Employment history was obtained from clinical interviews. WD was defined as unemployment, interruption of employment or premature cessation of employment due to SLE at any time after the diagnosis. SLE disease characteristics, presence of organ damage and Safety of Estrogens in Lupus Erythematosus National Assessment—SLE Disease Activity Index (SLEDAI) flare index were determined from the medical records. Self-reported quality of life (QoL) was performed using the Medical Outcomes Study Short Form-36 (SF-36). Demographic factors, disease characteristics, and QoL were compared between patients with and without WD using statistical analyses. Results: A total of 215 patients were recruited and the majority were Malay (60.5%), followed by Chinese (33.5%), Indian (4.5%) and others (n = 4, 1.9%). The prevalence of WD was 43.2% (n = 93) with 22.3% (n = 48) patients were unemployed at the time of study. Over half the patients with WD (n = 51, 54.8%) had onset of disability at <5 years from diagnosis. Patients with WD had significantly lower health-related QoL. The independent factors associated with WD were SLEDAI score at diagnosis, frequency of flare, Systemic Lupus International Collaborating Clinics score, being married, had lower education and lupus nephritis. Conclusion: We found a high rate of WD in patients with SLE and it was significantly associated with SLE-related factors, in particular higher disease activity, presence of renal involvement and organ damage.

KW - disability

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KW - nephritis

KW - quality of life

KW - work

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