What are the antioxidant status predictors' factors among male chronic obstructive pulmonary disease (COPD) patients?

Elham Pirabbasi, Mahin Najafiyan, Maria Cheraghi, Suzana Shahar, Zahara Abdul Manaf, Nor Fadilah Rajab, Roslina Abd. Manap

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6 Citations (Scopus)

Abstract

Imbalance between antioxidant and oxidative stress is a major risk factor for pathogenesis of some chronic diseases such as chronic obstructive pulmonary disease (COPD). This study aimed to determine antioxidant and oxidative stress status, and also theirs association with respiratory function of male COPD patients to find the antioxidant predictors' factors. A total of 149 subjects were involved in a cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. Results of the study showed that plasma vitamin C was low in most of the subjects (86.6%). Total antioxidant capacity was the lowest in COPD stage IV compare to other stages (p < 0.05). Level of plasma vitamin A (p= 0.012) and vitamin C (p= 0.007) were low in malnourished subjects. The predictors for total antioxidant capacity were forced vital capacity (FVC) % predicted and intake of ?-carotene (R2= 0.104, p= 0.002). Number of cigarette (pack/ year) and smoking index (number/ year) were not associated with total antioxidant capacity of this COPD population. Plasma oxidative stress as assessed plasma lipid peroxidation (LPO) was only positively correlated with plasma glutathione (p= 0.002). It might be a need to evaluate antioxidant status especially in older COPD patients to treat antioxidant deficiency which is leading to prevent COPD progression.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalGlobal journal of health science
Volume5
Issue number1
Publication statusPublished - Jan 2013

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Chronic Obstructive Pulmonary Disease
Antioxidants
Oxidative Stress
Ascorbic Acid
Malaysia
Vital Capacity
Carotenoids
Vitamin A
Tobacco Products
Lipid Peroxidation
Glutathione
Disease Progression
Chronic Disease
Cross-Sectional Studies
Smoking
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "What are the antioxidant status predictors' factors among male chronic obstructive pulmonary disease (COPD) patients?",
abstract = "Imbalance between antioxidant and oxidative stress is a major risk factor for pathogenesis of some chronic diseases such as chronic obstructive pulmonary disease (COPD). This study aimed to determine antioxidant and oxidative stress status, and also theirs association with respiratory function of male COPD patients to find the antioxidant predictors' factors. A total of 149 subjects were involved in a cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. Results of the study showed that plasma vitamin C was low in most of the subjects (86.6{\%}). Total antioxidant capacity was the lowest in COPD stage IV compare to other stages (p < 0.05). Level of plasma vitamin A (p= 0.012) and vitamin C (p= 0.007) were low in malnourished subjects. The predictors for total antioxidant capacity were forced vital capacity (FVC) {\%} predicted and intake of ?-carotene (R2= 0.104, p= 0.002). Number of cigarette (pack/ year) and smoking index (number/ year) were not associated with total antioxidant capacity of this COPD population. Plasma oxidative stress as assessed plasma lipid peroxidation (LPO) was only positively correlated with plasma glutathione (p= 0.002). It might be a need to evaluate antioxidant status especially in older COPD patients to treat antioxidant deficiency which is leading to prevent COPD progression.",
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AU - Najafiyan, Mahin

AU - Cheraghi, Maria

AU - Shahar, Suzana

AU - Abdul Manaf, Zahara

AU - Rajab, Nor Fadilah

AU - Abd. Manap, Roslina

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