Waldenstrom's Macroglobulinaemia Presenting as Demyelinating Polyradiculoneuropathy

S Fadilah S. Abdul Wahid, Raymond Azman Ali, I. Najihah, S. K. Cheong

Research output: Contribution to journalArticle

Abstract

Patients (particularly elderly) undergoing evaluation for peripheral neuropathy of unknown cause should be screened for the presence of a monoclonal protein (M protein). The association of a neuropathy and a paraproteinaemia such as Waldenstrom's Macroglobulinaemia (WM) is not uncommon with the former antedating the haematologic symptoms by several years. Response to treatment has varied from good to very poor. We describe a case of WM presenting as a subacute demyelinating peripheral neuropathy. There was prompt resolution of the neuropathy with intravenous immunoglobulin therapy. Subsequent treatment with cyclophosphamide and plasmapheresis resulted in complete clinical remission with no further neurological relapses.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalThe Medical journal of Malaysia
Volume57
Issue number2
Publication statusPublished - 1 Jun 2002
Externally publishedYes

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Polyradiculoneuropathy
Waldenstrom Macroglobulinemia
Peripheral Nervous System Diseases
Paraproteinemias
Passive Immunization
Plasmapheresis
Intravenous Immunoglobulins
Cyclophosphamide
Recurrence
Therapeutics
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Waldenstrom's Macroglobulinaemia Presenting as Demyelinating Polyradiculoneuropathy. / S. Abdul Wahid, S Fadilah; Ali, Raymond Azman; Najihah, I.; Cheong, S. K.

In: The Medical journal of Malaysia, Vol. 57, No. 2, 01.06.2002, p. 211-214.

Research output: Contribution to journalArticle

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