Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions

Hamizah Shahirah Hamezah, Lina Wati Durani, Nor Faeizah Ibrahim, Daijiro Yanagisawa, Tomoko Kato, Akihiko Shiino, Sachiko Tanaka, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Ikuo Tooyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Impairments in cognitive and locomotor functions usually occur with advanced age, as do changes in brain volume. This study was conducted to assess changes in brain volume, cognitive and locomotor functions, and oxidative stress levels in middle- to late-aged rats. Forty-four male Sprague-Dawley rats were divided into four groups: 14, 18, 23, and 27 months of age. 1H magnetic resonance imaging (MRI) was performed using a 7.0-Tesla MR scanner system. The volumes of the lateral ventricles, medial prefrontal cortex (mPFC), hippocampus, striatum, cerebellum, and whole brain were measured. Open field, object recognition, and Morris water maze tests were conducted to assess cognitive and locomotor functions. Blood was taken for measurements of malondialdehyde (MDA), protein carbonyl content, and antioxidant enzyme activity. The lateral ventricle volumes were larger, whereas the mPFC, hippocampus, and striatum volumes were smaller in 27-month-old rats than in 14-month-old rats. In behavioral tasks, the 27-month-old rats showed less exploratory activity and poorer spatial learning and memory than did the 14-month-old rats. Biochemical measurements likewise showed increased MDA and lower glutathione peroxidase (GPx) activity in the 27-month-old rats. In conclusion, age-related increases in oxidative stress, impairment in cognitive and locomotor functions, and changes in brain volume were observed, with the most marked impairments observed in later age.

Original languageEnglish
Pages (from-to)69-79
Number of pages11
JournalExperimental Gerontology
Volume99
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Cognition
Rats
Brain
Aging of materials
Lateral Ventricles
Oxidative stress
Prefrontal Cortex
Malondialdehyde
Hippocampus
Oxidative Stress
Glutathione Peroxidase
Object recognition
Cerebellum
Enzyme activity
Magnetic resonance
Sprague Dawley Rats
Antioxidants
Magnetic Resonance Imaging
Blood
Water

Keywords

  • Aging
  • Brain atrophy
  • Cognitive function
  • MRI

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

Hamezah, H. S., Durani, L. W., Ibrahim, N. F., Yanagisawa, D., Kato, T., Shiino, A., ... Tooyama, I. (2017). Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions. Experimental Gerontology, 99, 69-79. https://doi.org/10.1016/j.exger.2017.09.008

Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions. / Hamezah, Hamizah Shahirah; Durani, Lina Wati; Ibrahim, Nor Faeizah; Yanagisawa, Daijiro; Kato, Tomoko; Shiino, Akihiko; Tanaka, Sachiko; Ahmad Damanhuri, Mohd Hanafi; Ngah, Wan Zurinah Wan; Tooyama, Ikuo.

In: Experimental Gerontology, Vol. 99, 01.12.2017, p. 69-79.

Research output: Contribution to journalArticle

Hamezah, HS, Durani, LW, Ibrahim, NF, Yanagisawa, D, Kato, T, Shiino, A, Tanaka, S, Ahmad Damanhuri, MH, Ngah, WZW & Tooyama, I 2017, 'Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions', Experimental Gerontology, vol. 99, pp. 69-79. https://doi.org/10.1016/j.exger.2017.09.008
Hamezah, Hamizah Shahirah ; Durani, Lina Wati ; Ibrahim, Nor Faeizah ; Yanagisawa, Daijiro ; Kato, Tomoko ; Shiino, Akihiko ; Tanaka, Sachiko ; Ahmad Damanhuri, Mohd Hanafi ; Ngah, Wan Zurinah Wan ; Tooyama, Ikuo. / Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions. In: Experimental Gerontology. 2017 ; Vol. 99. pp. 69-79.
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