Vitamin e in sarcopenia: Current evidences on its role in prevention and treatment

Shy Cian Khor, Norwahidah Abdul Karim, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof, Suzana Makpol

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Sarcopenia is a geriatric syndrome that is characterized by gradual loss of muscle mass and strength with increasing age. Although the underlying mechanism is still unknown, the contribution of increased oxidative stress in advanced age has been recognized as one of the risk factors of sarcopenia. Thus, eliminating reactive oxygen species (ROS) can be a strategy to combat sarcopenia. In this review, we discuss the potential role of vitamin E in the prevention and treatment of sarcopenia. Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways. Previous studies have shown its possible beneficial effects on aging and age-related diseases. Although there are evidences suggesting an association between vitamin E and muscle health, they are still inconclusive compared to other more extensively studied chronic diseases such as neurodegenerative diseases and cardiovascular diseases. Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.

Original languageEnglish
Article number914853
JournalOxidative Medicine and Cellular Longevity
Volume2014
DOIs
Publication statusPublished - 2014

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Sarcopenia
Vitamin E
Vitamins
Muscle
Geriatrics
Health
Neurodegenerative diseases
Muscles
Oxidative stress
Muscle Strength
Therapeutics
Neurodegenerative Diseases
Reactive Oxygen Species
Oxidative Stress
Chronic Disease
Cardiovascular Diseases
Antioxidants
Aging of materials
Modulation
Association reactions

ASJC Scopus subject areas

  • Cell Biology
  • Ageing
  • Biochemistry

Cite this

Vitamin e in sarcopenia : Current evidences on its role in prevention and treatment. / Khor, Shy Cian; Abdul Karim, Norwahidah; Wan Ngah, Wan Zurinah; Mohd Yusof, Yasmin Anum; Makpol, Suzana.

In: Oxidative Medicine and Cellular Longevity, Vol. 2014, 914853, 2014.

Research output: Contribution to journalArticle

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