Vitamin E and factors affecting atherosclerosis in rabbits fed a cholesterol-rich diet

N. M. Ismail, Norzana Abd. Ghafar, Kamsiah Jaarin, J. H. Khine, G. Md Top

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The present study aims to examine the effects of a palm-oil-derived vitamin E mixture containing tocotrienol (∼70%) and tocopherol (∼30%) on plasma lipids and on the formation of atherosclerotic plaques in rabbits given a 2% cholesterol diet. Eighteen New Zealand White rabbits (2.2-2.8 kg) were divided into three groups; group 1 (control) was fed a normal diet, group 2 (AT) was fed a 2% cholesterol diet and group 3 (PV) was fed a 2% cholesterol diet with oral palm vitamin E (60 mg/kg body weight) given daily for 10 weeks. There were no differences in the total cholesterol and triacylglycerol levels between the AT and PV groups. The PV group had a significantly higher concentrations of HDL-c and a lower TC/HDL-c ratio compared to the AT group (P < 0.003). The aortic tissue content of cholesterol and atherosclerotic lesions were comparable in both the AT and PV groups. However, the PV group had a lower content of plasma and aortic tissue malondialdehyde (P < 0.005). Our findings suggest that despite a highly atherogenic diet, palm vitamin E improved some important plasma lipid parameters, reduced lipid peroxidation but did not have an effect on the atherosclerotic plaque formation.

Original languageEnglish
JournalInternational Journal of Food Sciences and Nutrition
Volume51
Issue numberSUPPL.
Publication statusPublished - 2000

Fingerprint

atherosclerosis
Vitamin E
vitamin E
Atherosclerosis
rabbits
Cholesterol
cholesterol
Diet
Rabbits
diet
Atherosclerotic Plaques
blood lipids
Tocotrienols
Atherogenic Diet
Lipids
tocotrienols
Tocopherols
New Zealand White rabbit
palm oils
Malondialdehyde

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Vitamin E and factors affecting atherosclerosis in rabbits fed a cholesterol-rich diet. / Ismail, N. M.; Abd. Ghafar, Norzana; Jaarin, Kamsiah; Khine, J. H.; Top, G. Md.

In: International Journal of Food Sciences and Nutrition, Vol. 51, No. SUPPL., 2000.

Research output: Contribution to journalArticle

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AU - Top, G. Md

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