Vitamin e and bone structural changes

An evidence-based review

Isa Naina Mohamed, Boekhtiar Borhanuddin, Ahmad Nazrun Shuid, Nur Farhana Mohd Fozi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose. This paper explores the effects of vitamin E on bone structural changes. Methods. A systematic review of the literature was conducted to identify relevant studies about vitamin E and osteoporosis/bone structural changes. A comprehensive search in Medline and CINAHL for relevant studies published between the years 1946 and 2012 was conducted. The main inclusion criteria were published in English, studies had to report the association or effect of vitamin E and osteoporosis-related bone changes, and the osteoporosis-related bone changes should be related to lifestyle variables, aging, or experimentally-induced conditions. Results. The literature search identified 561 potentially relevant articles, whereby 11 studies met the inclusion criteria. There were three human epidemiological studies and eight animal experimental studies included in this paper. Four animal studies reported positive bone structural changes with vitamin E supplementation. The rest of the studies had negative changes or no effect. Studies with positive changes reported better effects with tocotrienol vitamin E isomer supplementation. Conclusions. This evidence-based review underscores the potential of vitamin E being used for osteoporosis. The effect of one of the vitamin E isomers, tocotrienols, on bone structural changes warrants further exploration. Controlled human observational studies should be conducted to provide stronger evidence.

Original languageEnglish
Article number250584
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Vitamin E
Vitamins
Bone and Bones
Osteoporosis
Tocotrienols
Observational Studies
Life Style
Epidemiologic Studies

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Vitamin e and bone structural changes : An evidence-based review. / Naina Mohamed, Isa; Borhanuddin, Boekhtiar; Shuid, Ahmad Nazrun; Mohd Fozi, Nur Farhana.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2012, 250584, 2012.

Research output: Contribution to journalArticle

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