Abstract
Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence on a possible relationship between vitamin D deficiency and depression is growing. In this review, the authors summarized the evidence on the association between vitamin D status and depression in human observational studies, followed by clinical trials to evaluate the effects of vitamin D supplementation in treating depression. In conclusion, vitamin D deficiency may be associated with an increased risk or severity of depression. Supplementation of vitamin D may confer protection for depressed patients.
| Original language | English |
|---|---|
| Pages (from-to) | 888-897 |
| Number of pages | 10 |
| Journal | Current Drug Targets |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
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Keywords
- 1,25-dihydroxyvitamin D
- 25-hydroxyvitamin D
- Depression
- Mental health
- Vitamin D
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Clinical Biochemistry
Cite this
Vitamin D and depression : The evidence from an indirect clue to treatment strategy. / Wong, Sok Kuan; Kok Yong, Chin; Soelaiman, Ima Nirwana.
In: Current Drug Targets, Vol. 19, No. 8, 01.01.2018, p. 888-897.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Vitamin D and depression
T2 - The evidence from an indirect clue to treatment strategy
AU - Wong, Sok Kuan
AU - Kok Yong, Chin
AU - Soelaiman, Ima Nirwana
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence on a possible relationship between vitamin D deficiency and depression is growing. In this review, the authors summarized the evidence on the association between vitamin D status and depression in human observational studies, followed by clinical trials to evaluate the effects of vitamin D supplementation in treating depression. In conclusion, vitamin D deficiency may be associated with an increased risk or severity of depression. Supplementation of vitamin D may confer protection for depressed patients.
AB - Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence on a possible relationship between vitamin D deficiency and depression is growing. In this review, the authors summarized the evidence on the association between vitamin D status and depression in human observational studies, followed by clinical trials to evaluate the effects of vitamin D supplementation in treating depression. In conclusion, vitamin D deficiency may be associated with an increased risk or severity of depression. Supplementation of vitamin D may confer protection for depressed patients.
KW - 1,25-dihydroxyvitamin D
KW - 25-hydroxyvitamin D
KW - Depression
KW - Mental health
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85048952448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048952448&partnerID=8YFLogxK
U2 - 10.2174/1389450118666170913161030
DO - 10.2174/1389450118666170913161030
M3 - Review article
C2 - 28914205
AN - SCOPUS:85048952448
VL - 19
SP - 888
EP - 897
JO - Current Drug Targets
JF - Current Drug Targets
SN - 1389-4501
IS - 8
ER -