Vitamin D and depression

The evidence from an indirect clue to treatment strategy

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence on a possible relationship between vitamin D deficiency and depression is growing. In this review, the authors summarized the evidence on the association between vitamin D status and depression in human observational studies, followed by clinical trials to evaluate the effects of vitamin D supplementation in treating depression. In conclusion, vitamin D deficiency may be associated with an increased risk or severity of depression. Supplementation of vitamin D may confer protection for depressed patients.

Original languageEnglish
Pages (from-to)888-897
Number of pages10
JournalCurrent Drug Targets
Volume19
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Vitamin D
Depression
Vitamin D Deficiency
Vitamins
Therapeutics
Osteomalacia
Rickets
Sunlight
Health Care Costs
Antidepressive Agents
Observational Studies
Psychiatry
Fats
Quality of Life
Clinical Trials
Calcium
Recurrence
Mortality
Costs

Keywords

  • 1,25-dihydroxyvitamin D
  • 25-hydroxyvitamin D
  • Depression
  • Mental health
  • Vitamin D

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Vitamin D and depression : The evidence from an indirect clue to treatment strategy. / Wong, Sok Kuan; Kok Yong, Chin; Soelaiman, Ima Nirwana.

In: Current Drug Targets, Vol. 19, No. 8, 01.01.2018, p. 888-897.

Research output: Contribution to journalReview article

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