Vitamin A, C, E and risk of breast cancer according to menopausal status in Malaysia

Mohd Razif Shahril, Suhaina Sulaiman, Sharifah Wajihah Wafa, Sharifah Noor Akmal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vitamin A, C and E intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent and limited to developed countries with higher cancer incidence. Therefore, the aim of this study is to examine the association of premenopausal and postmenopausal breast cancer risk with vitamin A, C and E intake from dietary sources. This is a population based case-control study conducted in Malaysian population among 382 breast cancer patients and 382 control group. Dietary intake was assessed via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders were included in analysis. The results of this study shows a significant decreased risk of breast cancer among premenopausal (ORQ4 to Q1=0.38, 95% CI, 0.12 - 0.55, p-trend=0.001) and postmenopausal (ORQ4 to Q1=0.26, 95% CI, 0.03 - 0.75, p-trend=0.017) women was observed in the highest quartile of beta-carotene intake. Meanwhile, a higher intake of vitamin C showed significantly lowered risk only for premenopausal women (ORQ4 to Q1=0.13, 95% CI, 0.03 - 0.32, p-trend=0.001). As a conclusion, beta-carotene intake was independently related to pre- and postmenopausal breast cancer risk, while vitamin C intake was associated with decreased risk among premenopausal women only. However, no association was observed for vitamin A especially retinol and vitamin E intake from dietary sources.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalMalaysian Journal of Public Health Medicine
Volume16
Issue number2
Publication statusPublished - 2016

Fingerprint

Malaysia
Vitamin A
Ascorbic Acid
Breast Neoplasms
Vitamin E
Confidence Intervals
beta Carotene
Developed Countries
Population
Case-Control Studies
Logistic Models
Odds Ratio
Interviews
Food
Control Groups
Incidence
Neoplasms

Keywords

  • Beta-carotene
  • Breast cancer
  • Postmenopausal
  • Premenopausal
  • Retinol
  • Vitamin A
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Vitamin A, C, E and risk of breast cancer according to menopausal status in Malaysia. / Shahril, Mohd Razif; Sulaiman, Suhaina; Wafa, Sharifah Wajihah; Akmal, Sharifah Noor.

In: Malaysian Journal of Public Health Medicine, Vol. 16, No. 2, 2016, p. 72-79.

Research output: Contribution to journalArticle

Shahril, MR, Sulaiman, S, Wafa, SW & Akmal, SN 2016, 'Vitamin A, C, E and risk of breast cancer according to menopausal status in Malaysia', Malaysian Journal of Public Health Medicine, vol. 16, no. 2, pp. 72-79.
Shahril, Mohd Razif ; Sulaiman, Suhaina ; Wafa, Sharifah Wajihah ; Akmal, Sharifah Noor. / Vitamin A, C, E and risk of breast cancer according to menopausal status in Malaysia. In: Malaysian Journal of Public Health Medicine. 2016 ; Vol. 16, No. 2. pp. 72-79.
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