Visual functions and retinal morphology in patients with polypoidal choroidal vasculopathy seen in an age related macular degeneration referral centre of Malaysia

Sharanjeet-Kaur, Rituparna Ghoshal, Norliza Mohamad Fadzil, Somnath Ghosh, Roslin Azni Bt Abdul Aziz, Nor Fariza Ngah, Haliza Abdul Mutalib

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to evaluate visual functions and retinal morphology of Polypoidal Choroidal Vasculopathy (PCV) patients seen in an AMD referral centre of Malaysia and to further explore association between visual functions and optical coherence tomography (OCT) parameters in PCV eyes. In this single centre, cross sectional study, best corrected distance visual acuity (DVA), near vision acuity (NVA), reading speed (RS), and contrast sensitivity (CS) were measured in naïve PCV eyes. Selective parameters such as integrity of external limiting membrane (ELM), inner segment and outer segment junction (IS-OS), retinal pigment epithelium and Bruch's membrane (RPE-BM) complex, average retinal thickness (ART) and volume (ARV), central retinal thickness (CT), centre maximum (CTmax) and centre minimum (CTmin) thickness were assessed using spectral-domain OCT. Forty-three new PCV eyes of 42 patients were evaluated. Mean (±SD) DVA, NVA, CS, RS were 0.83 ± 0.35 logMAR, 0.77 ± 0.3 logMAR, 0.69 ±.26 log CS and 59.56 ±14 words per minutes respectively. ART and CT showed good correlation with DVA (r=0.571 & 0.546) and CS (r= 0.576 & 0.586). ARV and CTmax showed good correlation with CS (r=0.516 &, 0.513). The mean DVA, NVA and CS between three ELM and IS-OS status were significantly different (p=.002 & .000; p=.012 & .029; p=.005 & .001). In conclusion, present study reports visual functions and OCT characteristics of PCV patients in an AMD referral centre of Malaysia. Many of the quantitative and qualitative OCT parameters showed good association with the visual functions in eyes with PCV.

Original languageEnglish
Pages (from-to)124-134
Number of pages11
JournalMalaysian Journal of Public Health Medicine
Volume2018
Issue numberSpecialissue1
Publication statusPublished - 31 Mar 2018

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Contrast Sensitivity
Malaysia
Macular Degeneration
Referral and Consultation
Optical Coherence Tomography
Visual Acuity
Reading
Bruch Membrane
Membranes
Retinal Pigment Epithelium
Cross-Sectional Studies

Keywords

  • Ocular coherence tomography
  • Polypoidal choroidal vasculopathy
  • Visual functions

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Visual functions and retinal morphology in patients with polypoidal choroidal vasculopathy seen in an age related macular degeneration referral centre of Malaysia. / Sharanjeet-Kaur; Ghoshal, Rituparna; Mohamad Fadzil, Norliza; Ghosh, Somnath; Aziz, Roslin Azni Bt Abdul; Ngah, Nor Fariza; Abdul Mutalib, Haliza.

In: Malaysian Journal of Public Health Medicine, Vol. 2018, No. Specialissue1, 31.03.2018, p. 124-134.

Research output: Contribution to journalArticle

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abstract = "The aim of the present study was to evaluate visual functions and retinal morphology of Polypoidal Choroidal Vasculopathy (PCV) patients seen in an AMD referral centre of Malaysia and to further explore association between visual functions and optical coherence tomography (OCT) parameters in PCV eyes. In this single centre, cross sectional study, best corrected distance visual acuity (DVA), near vision acuity (NVA), reading speed (RS), and contrast sensitivity (CS) were measured in na{\"i}ve PCV eyes. Selective parameters such as integrity of external limiting membrane (ELM), inner segment and outer segment junction (IS-OS), retinal pigment epithelium and Bruch's membrane (RPE-BM) complex, average retinal thickness (ART) and volume (ARV), central retinal thickness (CT), centre maximum (CTmax) and centre minimum (CTmin) thickness were assessed using spectral-domain OCT. Forty-three new PCV eyes of 42 patients were evaluated. Mean (±SD) DVA, NVA, CS, RS were 0.83 ± 0.35 logMAR, 0.77 ± 0.3 logMAR, 0.69 ±.26 log CS and 59.56 ±14 words per minutes respectively. ART and CT showed good correlation with DVA (r=0.571 & 0.546) and CS (r= 0.576 & 0.586). ARV and CTmax showed good correlation with CS (r=0.516 &, 0.513). The mean DVA, NVA and CS between three ELM and IS-OS status were significantly different (p=.002 & .000; p=.012 & .029; p=.005 & .001). In conclusion, present study reports visual functions and OCT characteristics of PCV patients in an AMD referral centre of Malaysia. Many of the quantitative and qualitative OCT parameters showed good association with the visual functions in eyes with PCV.",
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