Virgin coconut oil and diabetic wound healing

Histopathological and biochemical analysis

Research output: Contribution to journalArticle

Abstract

Delayed wound healing (the diabetic ulcer) is one of the major complications of diabetes mellitus (DM), which has shown an increasing trend over previous decades to affect almost 15% of diabetic patients. Virgin coconut oil (VCO) is a natural oil rich in vitamins and antioxidants and possesses antimicrobial and antiviral activities. In the current study, we evaluated the effects of topical application of VCO on wound healing in diabetes induced Sprague-Dawley rats. A total of 72 animals were divided into 4 groups: i.e. (i) non-diabetic non-treated (NN), (ii) diabetic non-treated (DN), (iii) diabetic treated with VCO (VCO), and (iv) diabetic treated with silver sulfadiazine cream (SS). Wounds were inflicted on all groups using punch biopsy needles, and the animals were treated for 14 days. Wound closure rate (WCR) was measured on day 5, 10, and 14. Histological analysis was performed on day 7 and 14. Total protein content and superoxide dismutase (SOD) activity were measured on day 1, 7, and 14. WCR in VCO group was higher on all days compared to DN. Histological analysis revealed that VCO promoted reepithelialization and increased collagen content of wound tissue. Total protein content in VCO group was higher on day 7 and 14 compared to both DN and SS groups. VCO showed insignificant effects on SOD levels. In summary, VCO was found to be better than silver sulfadiazine cream in the healing of diabetic wounds via promoting re-epithelialization and collagen synthesize as well as increasing WCR and total protein content.

Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalEuropean Journal of Anatomy
Volume22
Issue number2
Publication statusPublished - 1 Mar 2018

Fingerprint

Wound Healing
Silver Sulfadiazine
Wounds and Injuries
Superoxide Dismutase
Collagen
Re-Epithelialization
coconut oil
Proteins
Needle Biopsy
Diabetes Complications
Vitamins
Ulcer
Antiviral Agents
Sprague Dawley Rats
Oils
Antioxidants

Keywords

  • Diabetes
  • Healing
  • Virgin coconut oil
  • Wound

ASJC Scopus subject areas

  • Anatomy

Cite this

Virgin coconut oil and diabetic wound healing : Histopathological and biochemical analysis. / Soliman, Amro Mohamed; Teoh, Seong Lin; Abd. Ghafar, Norzana; Das, Srijit.

In: European Journal of Anatomy, Vol. 22, No. 2, 01.03.2018, p. 135-144.

Research output: Contribution to journalArticle

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