Vincristine-induced vocal cord palsy case report and review of the literature

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Summary: Vincristine-induced vocal cord paralysis is a rare but serious complication. We report 2 patients with acute lymphoblastic leukemia who developed progressive stridor during induction chemotherapy. There were no clinical features of peripheral or autonomic neuropathy. Flexible laryngoscopy confirmed the diagnosis of bilateral vocal cord palsy; interestingly, the nerve conduction test revealed axonal motor neuropathy involving the median and common peroneal nerves in both patients. The first patient required prolonged ventilatory support necessitating unilateral cordectomy before extubation, whereas the second only required supplemental oxygen therapy. There was resolution of stridor in the first patient after cordectomy and gradual clinical improvement in the second. These cases illustrate that a high index of suspicion of vincristine-induced vocal cord palsy with prompt otolaryngology consultation for laryngoscopy is required in the diagnostic evaluation of a patient who has received vincristine.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume32
Issue number5
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Vocal Cord Paralysis
Vincristine
Laryngoscopy
Respiratory Sounds
Median Neuropathy
Peroneal Nerve
Induction Chemotherapy
Neural Conduction
Otolaryngology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Referral and Consultation
Oxygen

Keywords

  • Childhood leukemia
  • Vincristine
  • Vocal cord paralysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology
  • Medicine(all)

Cite this

@article{55b7b5d522df4e1cad959b27ebcd0ac7,
title = "Vincristine-induced vocal cord palsy case report and review of the literature",
abstract = "Summary: Vincristine-induced vocal cord paralysis is a rare but serious complication. We report 2 patients with acute lymphoblastic leukemia who developed progressive stridor during induction chemotherapy. There were no clinical features of peripheral or autonomic neuropathy. Flexible laryngoscopy confirmed the diagnosis of bilateral vocal cord palsy; interestingly, the nerve conduction test revealed axonal motor neuropathy involving the median and common peroneal nerves in both patients. The first patient required prolonged ventilatory support necessitating unilateral cordectomy before extubation, whereas the second only required supplemental oxygen therapy. There was resolution of stridor in the first patient after cordectomy and gradual clinical improvement in the second. These cases illustrate that a high index of suspicion of vincristine-induced vocal cord palsy with prompt otolaryngology consultation for laryngoscopy is required in the diagnostic evaluation of a patient who has received vincristine.",
keywords = "Childhood leukemia, Vincristine, Vocal cord paralysis",
author = "{Abdul Latiff}, Zarina and {Kamal Nor}, Norazlin and Jeevanan Jahendran and Hamidah Alias and Goh, {Bee See} and {Syed Zakaria}, {Syed Zulkifli} and {A. Jamal}, {A. Rahman}",
year = "2010",
month = "7",
doi = "10.1097/MPH.0b013e3181e01584",
language = "English",
volume = "32",
pages = "407--410",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Vincristine-induced vocal cord palsy case report and review of the literature

AU - Abdul Latiff, Zarina

AU - Kamal Nor, Norazlin

AU - Jahendran, Jeevanan

AU - Alias, Hamidah

AU - Goh, Bee See

AU - Syed Zakaria, Syed Zulkifli

AU - A. Jamal, A. Rahman

PY - 2010/7

Y1 - 2010/7

N2 - Summary: Vincristine-induced vocal cord paralysis is a rare but serious complication. We report 2 patients with acute lymphoblastic leukemia who developed progressive stridor during induction chemotherapy. There were no clinical features of peripheral or autonomic neuropathy. Flexible laryngoscopy confirmed the diagnosis of bilateral vocal cord palsy; interestingly, the nerve conduction test revealed axonal motor neuropathy involving the median and common peroneal nerves in both patients. The first patient required prolonged ventilatory support necessitating unilateral cordectomy before extubation, whereas the second only required supplemental oxygen therapy. There was resolution of stridor in the first patient after cordectomy and gradual clinical improvement in the second. These cases illustrate that a high index of suspicion of vincristine-induced vocal cord palsy with prompt otolaryngology consultation for laryngoscopy is required in the diagnostic evaluation of a patient who has received vincristine.

AB - Summary: Vincristine-induced vocal cord paralysis is a rare but serious complication. We report 2 patients with acute lymphoblastic leukemia who developed progressive stridor during induction chemotherapy. There were no clinical features of peripheral or autonomic neuropathy. Flexible laryngoscopy confirmed the diagnosis of bilateral vocal cord palsy; interestingly, the nerve conduction test revealed axonal motor neuropathy involving the median and common peroneal nerves in both patients. The first patient required prolonged ventilatory support necessitating unilateral cordectomy before extubation, whereas the second only required supplemental oxygen therapy. There was resolution of stridor in the first patient after cordectomy and gradual clinical improvement in the second. These cases illustrate that a high index of suspicion of vincristine-induced vocal cord palsy with prompt otolaryngology consultation for laryngoscopy is required in the diagnostic evaluation of a patient who has received vincristine.

KW - Childhood leukemia

KW - Vincristine

KW - Vocal cord paralysis

UR - http://www.scopus.com/inward/record.url?scp=77955908486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955908486&partnerID=8YFLogxK

U2 - 10.1097/MPH.0b013e3181e01584

DO - 10.1097/MPH.0b013e3181e01584

M3 - Article

VL - 32

SP - 407

EP - 410

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 5

ER -