Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy

Abd Fuaat Azliana, Zainul Rashid Mohd. Razi, Sabrina Florence Chandramaya, Wirda Indah Farouk, Alfian Nurwardah, Wong Yin Ping, Geok Chin Tan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Hypertensive disorder in pregnancy (HDP) represents the most common medical complication in pregnancy. It is the leading cause of maternal and perinatal mortality and morbidity. Vascular endothelial growth factor (VEGF) stimulates vascular endothelial cell growth, survival, and proliferation, and they are known to be expressed in human placenta. The aim of this study was to determine the VEGF expression in the placenta of hypertensive and normotensive patients. Materials and Methods: This is a retrospective, cross-sectional study from January 1, 2015 to December 31, 2015. A total of 30 placentae comprised of 15 hypertensive and 15 normotensive cases were assessed. VEGF expression in placenta was assessed by immunohistochemistry, and the number of syncytial knots was counted. Results: Our study showed an increased syncytial knot formation in the placenta of hypertensive mothers. VEGF expression was seen in syncytiotrophoblasts of 14 of the hypertensive cases (14/15, 93.3%), while only two of the normotensive cases were positive (2/15, 13.3%). There were no statistically significant differences in VEGF expression in other placenta cells, that is, cytotrophoblasts (P = 1.0), decidual cells (0.1394), maternal endothelial cells (0.5977), and fetal endothelial cells (P = 1.0). Conclusions: This study showed an increased number of syncytial knots is a consistent histological finding in the placenta of patient with HDP. VEGF expression was significantly increased in syncytiotrophoblasts in placenta of hypertensive group, and it could be used as a biomarker for hypertension.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalIndian Journal of Pathology and Microbiology
Volume60
Issue number4
DOIs
Publication statusPublished - 1 Oct 2017

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Placenta Diseases
Placenta
Vascular Endothelial Growth Factor A
Pregnancy
Trophoblasts
Endothelial Cells
Mothers
Pregnancy Complications
Maternal Mortality
Perinatal Mortality
Cell Survival
Cross-Sectional Studies
Biomarkers
Immunohistochemistry
Cell Proliferation
Hypertension
Morbidity

Keywords

  • Hypertension
  • immunohistochemistry
  • placenta
  • syncytiotrophoblasts
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy. / Azliana, Abd Fuaat; Mohd. Razi, Zainul Rashid; Chandramaya, Sabrina Florence; Farouk, Wirda Indah; Nurwardah, Alfian; Yin Ping, Wong; Tan, Geok Chin.

In: Indian Journal of Pathology and Microbiology, Vol. 60, No. 4, 01.10.2017, p. 515-520.

Research output: Contribution to journalArticle

Azliana, Abd Fuaat ; Mohd. Razi, Zainul Rashid ; Chandramaya, Sabrina Florence ; Farouk, Wirda Indah ; Nurwardah, Alfian ; Yin Ping, Wong ; Tan, Geok Chin. / Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy. In: Indian Journal of Pathology and Microbiology. 2017 ; Vol. 60, No. 4. pp. 515-520.
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AU - Yin Ping, Wong

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