Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix

Geok Chin Tan, Noor Akmal Sharifah, Mohd Sidik Shiran, Salwati Shuib, Ahmad Zailani Hatta, Hock Oon Paul-Ng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The differentiation between cervical intraepithelial neoplasia 3 (CIN 3) and early squamous cell carcinoma (SCC) of the cervix may be difficult in certain situations. Identification of invasion beyond the basement membrane is the gold standard for the diagnosis of the latter. The objective of this study was to determine whether the use of Ki-67 and p53 could help in solving the above dilemma. This was a retrospective study on 61 cases of cervical neoplasms comprising of 25 cases of CIN 3 and 36 SCC. All cases were evaluated by immunohistochemistry using Ki-67 and p53 monoclonal antibodies. Results showed that the differences of Ki-67 and p53 expression between CIN 3 and SCC were statistically significant. In conclusion, Ki-67 and p53 may serve as helpful adjuncts to routinely-stained histological sections in differentiating between CIN 3 and SCC.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume9
Issue number4
Publication statusPublished - 2008

Fingerprint

Cervical Intraepithelial Neoplasia
Cervix Uteri
Squamous Cell Carcinoma
Basement Membrane
Uterine Cervical Neoplasms
Retrospective Studies
Immunohistochemistry
Monoclonal Antibodies

Keywords

  • Cervical intraepithelial neoplasia
  • Cervical neoplasms
  • Ki-67
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix. / Tan, Geok Chin; Sharifah, Noor Akmal; Shiran, Mohd Sidik; Shuib, Salwati; Hatta, Ahmad Zailani; Paul-Ng, Hock Oon.

In: Asian Pacific Journal of Cancer Prevention, Vol. 9, No. 4, 2008, p. 781-784.

Research output: Contribution to journalArticle

Tan, Geok Chin ; Sharifah, Noor Akmal ; Shiran, Mohd Sidik ; Shuib, Salwati ; Hatta, Ahmad Zailani ; Paul-Ng, Hock Oon. / Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix. In: Asian Pacific Journal of Cancer Prevention. 2008 ; Vol. 9, No. 4. pp. 781-784.
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