Use of hyperbaric oxygen therapy (Hbot) in chronic diabetic wound-a randomised trial

Nik Hisamuddin Nik Ab Rahman, Wan Mohd Zahiruddin Wan Mohammad, Mohd Yazid Bajuri, Rahmah Shafee

Research output: Contribution to journalArticle

Abstract

Introduction: The purpose of this study was to investigate the effect of hyperbaric oxygen therapy (HBOT) towards diabetic foot ulcer (DFU) patients in addition to the standard wound care management. Methods: Fifty-eight diabetic patients with ulcers at Wagner Grade 2 and above involved in this study after presented at two study centres of tertiary teaching hospitals. The assigned patients received conventional wound care with additional HBOT given at 2.4 ATA for 90 minutes. Patients in the control group who received conventional wound care only were treated and observed for 30 days. The progress of wound healing was observed and measured at day 0, 10, 20 and 30 of study. The data collected were analysed using SPSS software (ver. 22) to study the association of HBOT towards healing of the diabetic foot ulcers. Results: Repeated Measures ANOVA analysis with Greenhouse-Geisser correction indicated that the means of wound size over time points (Day 0, 10, 20 and 30) among patients under HBOT group were statistically significantly different [F(1,61)=30.86, p<0.001)] compared to conventional therapy group. Multiple logistic regression analysis showed that HBOT group has nearly 44 times higher odds to achieve at least 30% wound size reduction within the study period (95%CI: 7.18, 268.97, p<0.001). Conclusion: The results obtained in this study indicated that as an adjunctive therapy to conventional wound care, HBOT affected the rate of healing in diabetic foot ulcers significantly in terms of wound size reduction when compared to administering the conventional wound care alone.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalMedical Journal of Malaysia
Volume74
Issue number5
Publication statusPublished - Oct 2019

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Hyperbaric Oxygenation
Wounds and Injuries
Diabetic Foot
Group Psychotherapy
Tertiary Care Centers
Teaching Hospitals
Wound Healing
Ulcer
Analysis of Variance
Software
Logistic Models
Regression Analysis
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rahman, N. H. N. A., Mohammad, W. M. Z. W., Bajuri, M. Y., & Shafee, R. (2019). Use of hyperbaric oxygen therapy (Hbot) in chronic diabetic wound-a randomised trial. Medical Journal of Malaysia, 74(5), 418-424.

Use of hyperbaric oxygen therapy (Hbot) in chronic diabetic wound-a randomised trial. / Rahman, Nik Hisamuddin Nik Ab; Mohammad, Wan Mohd Zahiruddin Wan; Bajuri, Mohd Yazid; Shafee, Rahmah.

In: Medical Journal of Malaysia, Vol. 74, No. 5, 10.2019, p. 418-424.

Research output: Contribution to journalArticle

Rahman, Nik Hisamuddin Nik Ab ; Mohammad, Wan Mohd Zahiruddin Wan ; Bajuri, Mohd Yazid ; Shafee, Rahmah. / Use of hyperbaric oxygen therapy (Hbot) in chronic diabetic wound-a randomised trial. In: Medical Journal of Malaysia. 2019 ; Vol. 74, No. 5. pp. 418-424.
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