Urogenital tuberculosis presenting as iga nephropathy and recurrent culture-negative urinary tract infections

Kon Ken Wong, Chuan Hun Ding, Zaili Zaki, Najihan Abdul Samat Muttaqillah, Yin Ping Wong, Ping Foo Wong

Research output: Contribution to journalArticle

Abstract

Tuberculosis is a public health problem that can cause extrapulmonary infections, including urogenital infections. We report here the case of a 29-year-old female with a 2-year history of dysuria and hematuria treated with multiple courses of antibiotics with urine cultures all negative. She was then diagnosed with IgA nephropathy based on a renal biopsy showing focal segmental glomeru-losclerosis and mesangial IgA deposits without granulomata. A polymerase chain reaction (PCR) for urinary tuberculosis was positive for Mycobacterium tuberculosis complex. A chest radiograph was normal. The patient was treated with isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months, followed by isoniazid and rifampicin for an additional 4 months. The patient responded well to treatment and her symptoms resolved completely. Urogenital tuberculosis should be considered in the patient who presents with dysuria and hematuria whose symptoms fail to improve with routine antimicrobials and who has routine urine cultures failing to show infection.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume50
Issue number5
Publication statusPublished - Sep 2019

Fingerprint

Urogenital Tuberculosis
Urinary Tract Infections
Dysuria
Isoniazid
Hematuria
Rifampin
Immunoglobulin A
Tuberculosis
Infection
Urine
Pyrazinamide
Ethambutol
Granuloma
Mycobacterium tuberculosis
Thorax
Public Health
Anti-Bacterial Agents
Kidney
Biopsy
Polymerase Chain Reaction

Keywords

  • IgA nephropathy
  • Mycobacterium tuberculosis
  • Tuberculosis
  • Urogenital

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Urogenital tuberculosis presenting as iga nephropathy and recurrent culture-negative urinary tract infections. / Wong, Kon Ken; Ding, Chuan Hun; Zaki, Zaili; Muttaqillah, Najihan Abdul Samat; Wong, Yin Ping; Wong, Ping Foo.

In: Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 50, No. 5, 09.2019, p. 881-885.

Research output: Contribution to journalArticle

@article{c00996147a4847aba0dea8647b32b0fc,
title = "Urogenital tuberculosis presenting as iga nephropathy and recurrent culture-negative urinary tract infections",
abstract = "Tuberculosis is a public health problem that can cause extrapulmonary infections, including urogenital infections. We report here the case of a 29-year-old female with a 2-year history of dysuria and hematuria treated with multiple courses of antibiotics with urine cultures all negative. She was then diagnosed with IgA nephropathy based on a renal biopsy showing focal segmental glomeru-losclerosis and mesangial IgA deposits without granulomata. A polymerase chain reaction (PCR) for urinary tuberculosis was positive for Mycobacterium tuberculosis complex. A chest radiograph was normal. The patient was treated with isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months, followed by isoniazid and rifampicin for an additional 4 months. The patient responded well to treatment and her symptoms resolved completely. Urogenital tuberculosis should be considered in the patient who presents with dysuria and hematuria whose symptoms fail to improve with routine antimicrobials and who has routine urine cultures failing to show infection.",
keywords = "IgA nephropathy, Mycobacterium tuberculosis, Tuberculosis, Urogenital",
author = "Wong, {Kon Ken} and Ding, {Chuan Hun} and Zaili Zaki and Muttaqillah, {Najihan Abdul Samat} and Wong, {Yin Ping} and Wong, {Ping Foo}",
year = "2019",
month = "9",
language = "English",
volume = "50",
pages = "881--885",
journal = "The Southeast Asian journal of tropical medicine and public health",
issn = "0125-1562",
publisher = "Southeast Asian Ministers of Education Organisation",
number = "5",

}

TY - JOUR

T1 - Urogenital tuberculosis presenting as iga nephropathy and recurrent culture-negative urinary tract infections

AU - Wong, Kon Ken

AU - Ding, Chuan Hun

AU - Zaki, Zaili

AU - Muttaqillah, Najihan Abdul Samat

AU - Wong, Yin Ping

AU - Wong, Ping Foo

PY - 2019/9

Y1 - 2019/9

N2 - Tuberculosis is a public health problem that can cause extrapulmonary infections, including urogenital infections. We report here the case of a 29-year-old female with a 2-year history of dysuria and hematuria treated with multiple courses of antibiotics with urine cultures all negative. She was then diagnosed with IgA nephropathy based on a renal biopsy showing focal segmental glomeru-losclerosis and mesangial IgA deposits without granulomata. A polymerase chain reaction (PCR) for urinary tuberculosis was positive for Mycobacterium tuberculosis complex. A chest radiograph was normal. The patient was treated with isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months, followed by isoniazid and rifampicin for an additional 4 months. The patient responded well to treatment and her symptoms resolved completely. Urogenital tuberculosis should be considered in the patient who presents with dysuria and hematuria whose symptoms fail to improve with routine antimicrobials and who has routine urine cultures failing to show infection.

AB - Tuberculosis is a public health problem that can cause extrapulmonary infections, including urogenital infections. We report here the case of a 29-year-old female with a 2-year history of dysuria and hematuria treated with multiple courses of antibiotics with urine cultures all negative. She was then diagnosed with IgA nephropathy based on a renal biopsy showing focal segmental glomeru-losclerosis and mesangial IgA deposits without granulomata. A polymerase chain reaction (PCR) for urinary tuberculosis was positive for Mycobacterium tuberculosis complex. A chest radiograph was normal. The patient was treated with isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months, followed by isoniazid and rifampicin for an additional 4 months. The patient responded well to treatment and her symptoms resolved completely. Urogenital tuberculosis should be considered in the patient who presents with dysuria and hematuria whose symptoms fail to improve with routine antimicrobials and who has routine urine cultures failing to show infection.

KW - IgA nephropathy

KW - Mycobacterium tuberculosis

KW - Tuberculosis

KW - Urogenital

UR - http://www.scopus.com/inward/record.url?scp=85076226623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076226623&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85076226623

VL - 50

SP - 881

EP - 885

JO - The Southeast Asian journal of tropical medicine and public health

JF - The Southeast Asian journal of tropical medicine and public health

SN - 0125-1562

IS - 5

ER -