Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity

Preliminary Report of a Prospective Longitudinal Study

Sabah Alharazy, Norella C T Kong, Marlyn Mohd, Shamsul Azhar Shah, Arbaiyah Ba'In, Abdul Halim Abdul Gafor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN-active or inactive-had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months. Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1. Results. A hundred patients completed the study. At each visit, uMCP-1 levels (pg/mg creatinine) were significantly higher in the active group especially with relapses and were significantly associated with proteinuria and renal SLEDAI-2K. Receiver operating characteristic (ROC) curves showed that uMCP-1 was a potential biomarker for LN. Whereas multiple logistic regression analysis showed that only proteinuria and serum albumin and not uMCP-1 were independent predictors of LN activity. Conclusion. uMCP-1 was increased in active LN. Although uMCP-1 was not an independent predictor for LN activity, it could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain. Larger and longer studies are indicated.

Original languageEnglish
Article number962046
JournalAutoimmune Diseases
Volume2015
DOIs
Publication statusPublished - 2015

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Lupus Nephritis
Chemokine CCL2
Longitudinal Studies
Urine
Prospective Studies
Kidney
Proteinuria
Biomarkers
Recurrence
Serologic Tests
Serum Albumin
ROC Curve
Creatinine
Logistic Models
Regression Analysis
Biopsy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology (miscellaneous)
  • Immunology

Cite this

Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity : Preliminary Report of a Prospective Longitudinal Study. / Alharazy, Sabah; Kong, Norella C T; Mohd, Marlyn; Shah, Shamsul Azhar; Ba'In, Arbaiyah; Abdul Gafor, Abdul Halim.

In: Autoimmune Diseases, Vol. 2015, 962046, 2015.

Research output: Contribution to journalArticle

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abstract = "This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN-active or inactive-had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months. Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1. Results. A hundred patients completed the study. At each visit, uMCP-1 levels (pg/mg creatinine) were significantly higher in the active group especially with relapses and were significantly associated with proteinuria and renal SLEDAI-2K. Receiver operating characteristic (ROC) curves showed that uMCP-1 was a potential biomarker for LN. Whereas multiple logistic regression analysis showed that only proteinuria and serum albumin and not uMCP-1 were independent predictors of LN activity. Conclusion. uMCP-1 was increased in active LN. Although uMCP-1 was not an independent predictor for LN activity, it could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain. Larger and longer studies are indicated.",
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