Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects

M. A. Newaz, N. N N Adeeb, N. Muslim, T. A. Razak, N. N. Htut

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    Abstract

    Uric acid produced by xanthine oxidase (also a source of superoxide radicals) has been known to increase in hypertensive patients. In this study we evaluated the possible involvement of uric acid and xanthine oxidase in the pathogenesis of hypertension by examining their association with mean arterial pressure (MAP) and factors related to blood pressure. These factors include age, quetelet index (weight/height2), cholesterol, creatinine, calcium (Ca), magnesium (Mg), sodium (Na), potassium (K) and urea. Fifty two (male-19, female-33) normal healthy individuals were studied. Correlation studies of demographic variables showed that age was positively correlated with MAP [r = 0.309, p = 0.026] and cholesterol [r = 0.503, p = 0.000] while quetelet index was positively correlated with age [r = 0.422, p = 0.000] MAP [r = 0.331, p = 0.016] and xanthine oxidase [r = 0.331, p = 0.016]. MAP was positively correlated with uric acid [r = 0.511, p = 0.000], cholesterol [r = 0.492, p = 0.000] and xanthine oxidase enzyme activity [r = 0.388, p = 0.004] and negatively correlated with plasma calcium [r = 0.603, p = 0.000]. Correlation studies of measured parameters with uric acid and xanthine oxidase showed that uric acid was positively correlated with creatinine [r = 0.627, p = 0.000], plasma magnesium [r = 0.442, p = 0.001] and negatively correlated with plasma calcium [r = 0.546, p = 0.000] while xanthine oxidase was negatively correlated with plasma calcium [r = 0.404, p = 0.003] and plasma sodium [r = 0.288, p = 0.038]. Stepwise multiple regression with MAP as dependent variable showed that 65% of total variability of blood pressure can be accounted for by plasma calcium, cholesterol, creatinine, plasma K, plasma Na, uric acid and xanthine oxidase in order of increasing R2 [xanthine oxidase: T-value = 3.26, R2 = 0.653]. It can be concluded that in normotensive subjects, uric acid and xanthine oxidase have significant association with blood pressure and thus are one of the many factors which are involved in the cause or effect of hypertension.

    Original languageEnglish
    Pages (from-to)1035-1050
    Number of pages16
    JournalClinical and Experimental Hypertension
    Volume18
    Issue number8
    Publication statusPublished - Nov 1996

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    Xanthine Oxidase
    Uric Acid
    Hypertension
    Arterial Pressure
    Calcium
    Cholesterol
    Creatinine
    Blood Pressure
    Magnesium
    Body Mass Index
    Sodium
    Age Factors
    Superoxides
    Urea
    Potassium
    Demography
    Weights and Measures
    Enzymes

    ASJC Scopus subject areas

    • Internal Medicine

    Cite this

    Newaz, M. A., Adeeb, N. N. N., Muslim, N., Razak, T. A., & Htut, N. N. (1996). Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects. Clinical and Experimental Hypertension, 18(8), 1035-1050.

    Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects. / Newaz, M. A.; Adeeb, N. N N; Muslim, N.; Razak, T. A.; Htut, N. N.

    In: Clinical and Experimental Hypertension, Vol. 18, No. 8, 11.1996, p. 1035-1050.

    Research output: Contribution to journalArticle

    Newaz, MA, Adeeb, NNN, Muslim, N, Razak, TA & Htut, NN 1996, 'Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects', Clinical and Experimental Hypertension, vol. 18, no. 8, pp. 1035-1050.
    Newaz, M. A. ; Adeeb, N. N N ; Muslim, N. ; Razak, T. A. ; Htut, N. N. / Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects. In: Clinical and Experimental Hypertension. 1996 ; Vol. 18, No. 8. pp. 1035-1050.
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    abstract = "Uric acid produced by xanthine oxidase (also a source of superoxide radicals) has been known to increase in hypertensive patients. In this study we evaluated the possible involvement of uric acid and xanthine oxidase in the pathogenesis of hypertension by examining their association with mean arterial pressure (MAP) and factors related to blood pressure. These factors include age, quetelet index (weight/height2), cholesterol, creatinine, calcium (Ca), magnesium (Mg), sodium (Na), potassium (K) and urea. Fifty two (male-19, female-33) normal healthy individuals were studied. Correlation studies of demographic variables showed that age was positively correlated with MAP [r = 0.309, p = 0.026] and cholesterol [r = 0.503, p = 0.000] while quetelet index was positively correlated with age [r = 0.422, p = 0.000] MAP [r = 0.331, p = 0.016] and xanthine oxidase [r = 0.331, p = 0.016]. MAP was positively correlated with uric acid [r = 0.511, p = 0.000], cholesterol [r = 0.492, p = 0.000] and xanthine oxidase enzyme activity [r = 0.388, p = 0.004] and negatively correlated with plasma calcium [r = 0.603, p = 0.000]. Correlation studies of measured parameters with uric acid and xanthine oxidase showed that uric acid was positively correlated with creatinine [r = 0.627, p = 0.000], plasma magnesium [r = 0.442, p = 0.001] and negatively correlated with plasma calcium [r = 0.546, p = 0.000] while xanthine oxidase was negatively correlated with plasma calcium [r = 0.404, p = 0.003] and plasma sodium [r = 0.288, p = 0.038]. Stepwise multiple regression with MAP as dependent variable showed that 65{\%} of total variability of blood pressure can be accounted for by plasma calcium, cholesterol, creatinine, plasma K, plasma Na, uric acid and xanthine oxidase in order of increasing R2 [xanthine oxidase: T-value = 3.26, R2 = 0.653]. It can be concluded that in normotensive subjects, uric acid and xanthine oxidase have significant association with blood pressure and thus are one of the many factors which are involved in the cause or effect of hypertension.",
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