Update on statins: Hope for osteoporotic fracture healing treatment

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fracture healing is a process of recovering injured bone tissue forms and functions. Osteoporosis can delay the healing process, which contributes to personal suffering and loss of activities. Osteoporosis patients tend to lose bone mass at the metaphyseal region which require treatment to increase bone mass. Postmenopausal osteoporosis is the most common osteoporosis that occurs in women which subsequently resulted in fractures even under slight trauma. Estrogen Replacement Therapy (ERT), the recommended therapy for postmenopausal osteoporosis, is associated with higher risk of breast cancer, ovarian cancer and cardiovascular diseases. As osteoporotic fractures are becoming a public health issue, alternative treatment is now being thoroughly explored. The potential agent is statins, the HMG-CoA reductase inhibitor which is widely used for hypercholesterolemia treatment. Statins have been found to increase bone mass by stimulation of Bone morphogenetic protein-2 (BMP-2) expression and Vascular Endothelial Growth Factor (VEGF) production. However, these bone forming effects were achieved at very high systemic doses. Therefore, studies on locally applied statins are required to further explore the ability of statins to stimulate bone formation at acceptable doses for better fracture healing. This review highlights the animal and clinical studies on fracture healing promotions by statins and the mechanisms involved.

Original languageEnglish
Pages (from-to)1524-1532
Number of pages9
JournalCurrent Drug Targets
Volume14
Issue number13
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Hope
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Osteoporotic Fractures
Fracture Healing
Bone
Bone and Bones
Osteoporosis
Postmenopausal Osteoporosis
Therapeutics
Ovarian Diseases
Bone Morphogenetic Protein 2
Estrogen Replacement Therapy
Aptitude
Public health
Hypercholesterolemia
Psychological Stress
Osteogenesis
Ovarian Neoplasms
Vascular Endothelial Growth Factor A
Estrogens

Keywords

  • BMP-2
  • Fracture healing
  • HMG-COA reductase inhibitor
  • Osteoporosis
  • VEGF

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Update on statins : Hope for osteoporotic fracture healing treatment. / Ibrahim, Nurul Izzah; Mohamed, Norazlina; Shuid, Ahmad Nazrun.

In: Current Drug Targets, Vol. 14, No. 13, 12.2013, p. 1524-1532.

Research output: Contribution to journalArticle

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