Unexpected epithelial membrane antigen (EMA) and cytokeratin expression in a case of infantile acute monoblastic leukaemia

S. K. Cheong, S. F. Chin, O. Azizon, O. Ainoon, Noor Hamidah Hussin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A previously healthy eleven month old male Malay infant presented with fever, upper respiratory tract infection and right knee swelling. Pallor, bilateral proptosis, hepatosplenomegaly, multiple scalp swellings and a right cheek swelling were observed. Investigations revealed that he had acute monoblastic leukemia or FAB M5a. Immunophenotyping by flow cytometry showed that the blast cells were positive for CD45, CD13, CD33, HLA-DR, CD11c, CD71, EMA, and Cytokeratin. They were negative for CD34, CD19, CD10, CD22, CD2, CD3, CD4, CD7, CD8, CD61, NK, Glycophorin A, and CD14. The monoblasts were used to evaluate anti-EMA and anti-cytokeratin. They were unexpectedly found to be positive. Acute monoblastic leukaemias are well known to show extramedullary infiltration and this may be their primary mode of presentation. Thus, in immunochemostry, when using EMA and cytokeratin expression in the differential diagnosis of neoplastic diseases, it is important to consider that monoblasts may express these markers as illustrated by this case.

Original languageEnglish
Pages (from-to)223-225
Number of pages3
JournalHematology
Volume1
Issue number3
Publication statusPublished - 1996

Fingerprint

Leukemia, Monocytic, Acute
Mucin-1
Keratins
Monocyte-Macrophage Precursor Cells
Glycophorin
Pallor
Immunophenotyping
Exophthalmos
Cheek
HLA-DR Antigens
Scalp
Respiratory Tract Infections
Knee
Flow Cytometry
Differential Diagnosis
Fever

Keywords

  • Acute monoblastic leukaemia
  • Cytokeratin
  • EMA

ASJC Scopus subject areas

  • Hematology

Cite this

Cheong, S. K., Chin, S. F., Azizon, O., Ainoon, O., & Hussin, N. H. (1996). Unexpected epithelial membrane antigen (EMA) and cytokeratin expression in a case of infantile acute monoblastic leukaemia. Hematology, 1(3), 223-225.

Unexpected epithelial membrane antigen (EMA) and cytokeratin expression in a case of infantile acute monoblastic leukaemia. / Cheong, S. K.; Chin, S. F.; Azizon, O.; Ainoon, O.; Hussin, Noor Hamidah.

In: Hematology, Vol. 1, No. 3, 1996, p. 223-225.

Research output: Contribution to journalArticle

Cheong, SK, Chin, SF, Azizon, O, Ainoon, O & Hussin, NH 1996, 'Unexpected epithelial membrane antigen (EMA) and cytokeratin expression in a case of infantile acute monoblastic leukaemia', Hematology, vol. 1, no. 3, pp. 223-225.
Cheong, S. K. ; Chin, S. F. ; Azizon, O. ; Ainoon, O. ; Hussin, Noor Hamidah. / Unexpected epithelial membrane antigen (EMA) and cytokeratin expression in a case of infantile acute monoblastic leukaemia. In: Hematology. 1996 ; Vol. 1, No. 3. pp. 223-225.
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