Understanding the pathophysiology of premature ejaculation: Bridging the link between pharmacological and psychological interventions

Farid Yusof, Hatta Sidi, Srijit Das, Marhani Midin, Jaya Kumar, Muhammd Hizri Hatta

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Premature ejaculation (PE) is one of the commonest male sexual dysfunctions. It is characterized by ejaculation which occurs before or soon after vaginal penetration, which causes significant psychological distress to the individual, and his partner. The exact cause of PE is still unknown but several mechanisms are proposed, and these involve complex interactions of neurophysiological, psychosocial, and cognitive factors. We discuss the role of serotonin, nitric oxide, phosphodiesterase enzymes and other neurotransmitters. Treatment of PE tends to co-occur with other sexual difficulties, especially erectile dysfunction (ED). Treatment with selective serotonin reuptake inhibitors (SSRIs) and Dapoxitene are also discussed in detail. The treatment strategy requires a comprehensive holistic approach incorporating both combination of psychopharmacological agent and cognitive-behavioral therapy (CBT). The present review highlights the integration of the hypothalamic-neural and reverberating emotional circuit and discusses the etiology and treatment for patients with PE.

Original languageEnglish
Pages (from-to)856-864
Number of pages9
JournalCurrent Drug Targets
Volume19
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Premature Ejaculation
Phosphoric Diester Hydrolases
Serotonin Uptake Inhibitors
Neurotransmitter Agents
Serotonin
Nitric Oxide
Pharmacology
Psychology
Networks (circuits)
Enzymes
Ejaculation
Cognitive Therapy
Erectile Dysfunction
Therapeutics

Keywords

  • Cognitive behaviour therapy
  • Dopexetine
  • Erectile dysfunction
  • Pathophysiology
  • Premature ejaculation
  • SSRIs

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Understanding the pathophysiology of premature ejaculation : Bridging the link between pharmacological and psychological interventions. / Yusof, Farid; Sidi, Hatta; Das, Srijit; Midin, Marhani; Kumar, Jaya; Hatta, Muhammd Hizri.

In: Current Drug Targets, Vol. 19, No. 8, 01.01.2018, p. 856-864.

Research output: Contribution to journalReview article

@article{0b46dc574c734559a63b67282f75b50c,
title = "Understanding the pathophysiology of premature ejaculation: Bridging the link between pharmacological and psychological interventions",
abstract = "Premature ejaculation (PE) is one of the commonest male sexual dysfunctions. It is characterized by ejaculation which occurs before or soon after vaginal penetration, which causes significant psychological distress to the individual, and his partner. The exact cause of PE is still unknown but several mechanisms are proposed, and these involve complex interactions of neurophysiological, psychosocial, and cognitive factors. We discuss the role of serotonin, nitric oxide, phosphodiesterase enzymes and other neurotransmitters. Treatment of PE tends to co-occur with other sexual difficulties, especially erectile dysfunction (ED). Treatment with selective serotonin reuptake inhibitors (SSRIs) and Dapoxitene are also discussed in detail. The treatment strategy requires a comprehensive holistic approach incorporating both combination of psychopharmacological agent and cognitive-behavioral therapy (CBT). The present review highlights the integration of the hypothalamic-neural and reverberating emotional circuit and discusses the etiology and treatment for patients with PE.",
keywords = "Cognitive behaviour therapy, Dopexetine, Erectile dysfunction, Pathophysiology, Premature ejaculation, SSRIs",
author = "Farid Yusof and Hatta Sidi and Srijit Das and Marhani Midin and Jaya Kumar and Hatta, {Muhammd Hizri}",
year = "2018",
month = "1",
day = "1",
doi = "10.2174/1389450117666161215161108",
language = "English",
volume = "19",
pages = "856--864",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Understanding the pathophysiology of premature ejaculation

T2 - Bridging the link between pharmacological and psychological interventions

AU - Yusof, Farid

AU - Sidi, Hatta

AU - Das, Srijit

AU - Midin, Marhani

AU - Kumar, Jaya

AU - Hatta, Muhammd Hizri

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Premature ejaculation (PE) is one of the commonest male sexual dysfunctions. It is characterized by ejaculation which occurs before or soon after vaginal penetration, which causes significant psychological distress to the individual, and his partner. The exact cause of PE is still unknown but several mechanisms are proposed, and these involve complex interactions of neurophysiological, psychosocial, and cognitive factors. We discuss the role of serotonin, nitric oxide, phosphodiesterase enzymes and other neurotransmitters. Treatment of PE tends to co-occur with other sexual difficulties, especially erectile dysfunction (ED). Treatment with selective serotonin reuptake inhibitors (SSRIs) and Dapoxitene are also discussed in detail. The treatment strategy requires a comprehensive holistic approach incorporating both combination of psychopharmacological agent and cognitive-behavioral therapy (CBT). The present review highlights the integration of the hypothalamic-neural and reverberating emotional circuit and discusses the etiology and treatment for patients with PE.

AB - Premature ejaculation (PE) is one of the commonest male sexual dysfunctions. It is characterized by ejaculation which occurs before or soon after vaginal penetration, which causes significant psychological distress to the individual, and his partner. The exact cause of PE is still unknown but several mechanisms are proposed, and these involve complex interactions of neurophysiological, psychosocial, and cognitive factors. We discuss the role of serotonin, nitric oxide, phosphodiesterase enzymes and other neurotransmitters. Treatment of PE tends to co-occur with other sexual difficulties, especially erectile dysfunction (ED). Treatment with selective serotonin reuptake inhibitors (SSRIs) and Dapoxitene are also discussed in detail. The treatment strategy requires a comprehensive holistic approach incorporating both combination of psychopharmacological agent and cognitive-behavioral therapy (CBT). The present review highlights the integration of the hypothalamic-neural and reverberating emotional circuit and discusses the etiology and treatment for patients with PE.

KW - Cognitive behaviour therapy

KW - Dopexetine

KW - Erectile dysfunction

KW - Pathophysiology

KW - Premature ejaculation

KW - SSRIs

UR - http://www.scopus.com/inward/record.url?scp=85048945978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048945978&partnerID=8YFLogxK

U2 - 10.2174/1389450117666161215161108

DO - 10.2174/1389450117666161215161108

M3 - Review article

C2 - 27993112

AN - SCOPUS:85048945978

VL - 19

SP - 856

EP - 864

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

IS - 8

ER -