Umbilical vein oxytocin in the management of retained placenta: an alternative to manual removal of placenta?

Pei Shan Lim, Surinder Singh, Alice Lee, Muhammad Abdul Jamil Muhammad Yassin

    Research output: Contribution to journalArticle

    Abstract

    Purpose: Retained placenta is potentially life threatening due to possible complications associated with manual removal. Our aim was to determine whether umbilical vein injection of oxytocin in saline reduces the need for manual removal of placenta. Methods: This was a randomised controlled trial conducted at a tertiary hospital from December 2002 to March 2004. A total of 61 women delivering singletons, who had no sign of placental separation 20 min after vaginal delivery, were randomised to receive either intra-umbilical oxytocin 100 IU diluted in 30 ml of saline or controlled cord traction only. Manual removal was done if the placenta was not expelled in another 30 min in both arms. Results: There was a significant reduction in the rate of subsequent manual removal of placenta (30 vs. 67.7%, p < 0.05), incidence of uterine atony (3.3 vs. 25.8%, p < 0.05) and the need for uterotonic agents (33.3 vs. 64.5%, p < 0.05) in the oxytocin group when compared with the control group. No significant differences were found in the need for blood transfusion, uterine curettage, incidence of postpartum haemorrhage and haemoglobin level reduction. Conclusion: Intra-umbilical vein oxytocin injection is clinically effective for the management of a retained placenta.

    Original languageEnglish
    Pages (from-to)1-7
    Number of pages7
    JournalArchives of Gynecology and Obstetrics
    DOIs
    Publication statusAccepted/In press - 2010

    Fingerprint

    Retained Placenta
    Umbilical Veins
    Oxytocin
    Placenta
    Uterine Inertia
    Umbilicus
    Postpartum Hemorrhage
    Injections
    Curettage
    Incidence
    Traction
    Tertiary Care Centers
    Blood Transfusion
    Hemoglobins
    Randomized Controlled Trials
    Control Groups

    Keywords

    • Intra-umbilical
    • Oxytocin
    • Placenta
    • Retained
    • Umbilical vein

    ASJC Scopus subject areas

    • Obstetrics and Gynaecology

    Cite this

    Umbilical vein oxytocin in the management of retained placenta : an alternative to manual removal of placenta? / Lim, Pei Shan; Singh, Surinder; Lee, Alice; Muhammad Yassin, Muhammad Abdul Jamil.

    In: Archives of Gynecology and Obstetrics, 2010, p. 1-7.

    Research output: Contribution to journalArticle

    Lim, Pei Shan ; Singh, Surinder ; Lee, Alice ; Muhammad Yassin, Muhammad Abdul Jamil. / Umbilical vein oxytocin in the management of retained placenta : an alternative to manual removal of placenta?. In: Archives of Gynecology and Obstetrics. 2010 ; pp. 1-7.
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    abstract = "Purpose: Retained placenta is potentially life threatening due to possible complications associated with manual removal. Our aim was to determine whether umbilical vein injection of oxytocin in saline reduces the need for manual removal of placenta. Methods: This was a randomised controlled trial conducted at a tertiary hospital from December 2002 to March 2004. A total of 61 women delivering singletons, who had no sign of placental separation 20 min after vaginal delivery, were randomised to receive either intra-umbilical oxytocin 100 IU diluted in 30 ml of saline or controlled cord traction only. Manual removal was done if the placenta was not expelled in another 30 min in both arms. Results: There was a significant reduction in the rate of subsequent manual removal of placenta (30 vs. 67.7{\%}, p < 0.05), incidence of uterine atony (3.3 vs. 25.8{\%}, p < 0.05) and the need for uterotonic agents (33.3 vs. 64.5{\%}, p < 0.05) in the oxytocin group when compared with the control group. No significant differences were found in the need for blood transfusion, uterine curettage, incidence of postpartum haemorrhage and haemoglobin level reduction. Conclusion: Intra-umbilical vein oxytocin injection is clinically effective for the management of a retained placenta.",
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