Two months aerobic exercise improves endothelial function and reduces oxidative dna damage in women with elevated blood pressure

Amilia Aminuddin, Zaiton Zakaria, Nor Anita Megat Mohd Nordin, Aminuddin Abdul Hamid Karim, Oteh Maskon, Tan Sook Pei, Fazalina Mohd. Fadzilah

Research output: Contribution to journalArticle

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Abstract

Background: Regular aerobic exercise has been shown to improve endothelial function and reduce oxidative stress in hypertensive patients. However, the information regarding the amount of exercise that is needed to produce this adaptation is scarce. Patient and Methods: Thirteen women (35 to 60 years of age) with elevated systolic blood pressure (SBP) were recruited. Six women underwent four weeks aerobic exercise (EG) three times per week at 50% heart rate reserve (HRR) for 30 minutes per session, which was then increased to 70% HRR for 45 minutes per session for another four weeks. Seven women served as control group (CG). Flow mediated dilation (FMD) and plasma von Willebrand Factor (vWF) were measured as the index of endothelial function. Urine 8-hydroxydeoxyguanosine (8-OHdG) was determined as the measure of oxidative DNA damage. Baseline measurements were repeated at four and eight weeks. ANOVA repeated measures via SPSS version 15 was used for data analysis and the level of P<o.05 was considered as statistically significant. Results: At baseline, there were insignificant differences in all parameters between the groups: age (EG=48.17±6.21 vs. CG=50.00±8.29 Years, p=0.84), resting SBP (EG=136.00±7.69 vs.CG=133.57±9.81 mmHg, p=0.73), FMD (EG=2.io±3.ii CG.=2.01±5.50 %, P=o.73), plasma vWF (EG=51.72±28.60 vs. CG=49.68±30.48 %, p=0.84) and urine 8-OHdG (EG=6.58±2.26 vs. CG=7.85±2.50 ng/mg creatinine, P=o.34). After intervention, significant reduction was found for plasma vWF (EG=4i.i2±22.35 vs. CG=56.70±22.35 %, P<o.05) and urine 8-OHdG (EG=433±o.79 vs. CG=7.02±1.73 ng/mg creatinine, P<o.05). Conclusion: Two months aerobic training using the prescribed exercise regime increased endothelial function and reduced oxidative DNA damage in women with elevated SBP.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalNew Iraqi Journal of Medicine
Volume7
Issue number1
Publication statusPublished - Apr 2011

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Exercise
Blood Pressure
Control Groups
von Willebrand Factor
Urine
DNA Damage
Dilatation
Creatinine
Heart Rate
Analysis of Variance
Oxidative Stress
Age Groups

Keywords

  • Aerobic exercise
  • Cardiovascular
  • DNA damage
  • Endothelial function
  • Hypertension
  • Physiology
  • Women

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Two months aerobic exercise improves endothelial function and reduces oxidative dna damage in women with elevated blood pressure. / Aminuddin, Amilia; Zakaria, Zaiton; Mohd Nordin, Nor Anita Megat; Hamid Karim, Aminuddin Abdul; Maskon, Oteh; Pei, Tan Sook; Mohd. Fadzilah, Fazalina.

In: New Iraqi Journal of Medicine, Vol. 7, No. 1, 04.2011, p. 52-59.

Research output: Contribution to journalArticle

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