Turbinate-Specific IgE in Normal and Rhinitic Patients

Aneeza Khairiyah Wan Hamizan, Janet Rimmer, Raquel Alvarado, William A. Sewell, Jessica Tatersall, Henry P. Barham, Larry Kalish, Richard J. Harvey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. Objective: The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. Methods: A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis. Results: A total of 160 patients (41.89 ± 14.65 years, 36.9% females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08–0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95% confidence interval: 0.84–0.90) with 90% sensitivity and 89% negative predictive value. Conclusion: Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.

Original languageEnglish
JournalAmerican Journal of Rhinology and Allergy
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Turbinates
Immunoglobulin E
Biopsy
Nose
Nasal Mucosa
Mites
Rhinitis
Poaceae
Dust
Immunoassay
Allergens
Area Under Curve
Epithelium
Cross-Sectional Studies
Confidence Intervals

Keywords

  • allergen
  • allergic rhinitis
  • asymptomatic
  • immunoglobulin E
  • inferior turbinate
  • local allergic rhinitis
  • nasal symptoms
  • receiver operating curve
  • tissue biopsy
  • tissue sIgE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

Cite this

Wan Hamizan, A. K., Rimmer, J., Alvarado, R., Sewell, W. A., Tatersall, J., Barham, H. P., ... Harvey, R. J. (2019). Turbinate-Specific IgE in Normal and Rhinitic Patients. American Journal of Rhinology and Allergy. https://doi.org/10.1177/1945892418825224

Turbinate-Specific IgE in Normal and Rhinitic Patients. / Wan Hamizan, Aneeza Khairiyah; Rimmer, Janet; Alvarado, Raquel; Sewell, William A.; Tatersall, Jessica; Barham, Henry P.; Kalish, Larry; Harvey, Richard J.

In: American Journal of Rhinology and Allergy, 01.01.2019.

Research output: Contribution to journalArticle

Wan Hamizan, Aneeza Khairiyah ; Rimmer, Janet ; Alvarado, Raquel ; Sewell, William A. ; Tatersall, Jessica ; Barham, Henry P. ; Kalish, Larry ; Harvey, Richard J. / Turbinate-Specific IgE in Normal and Rhinitic Patients. In: American Journal of Rhinology and Allergy. 2019.
@article{d1f2c94fd0204f46a6e53f1f384b8526,
title = "Turbinate-Specific IgE in Normal and Rhinitic Patients",
abstract = "Background: Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. Objective: The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. Methods: A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis. Results: A total of 160 patients (41.89 ± 14.65 years, 36.9{\%} females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08–0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95{\%} confidence interval: 0.84–0.90) with 90{\%} sensitivity and 89{\%} negative predictive value. Conclusion: Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.",
keywords = "allergen, allergic rhinitis, asymptomatic, immunoglobulin E, inferior turbinate, local allergic rhinitis, nasal symptoms, receiver operating curve, tissue biopsy, tissue sIgE",
author = "{Wan Hamizan}, {Aneeza Khairiyah} and Janet Rimmer and Raquel Alvarado and Sewell, {William A.} and Jessica Tatersall and Barham, {Henry P.} and Larry Kalish and Harvey, {Richard J.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/1945892418825224",
language = "English",
journal = "American Journal of Rhinology and Allergy",
issn = "1945-8924",
publisher = "OceanSide Publications Inc.",

}

TY - JOUR

T1 - Turbinate-Specific IgE in Normal and Rhinitic Patients

AU - Wan Hamizan, Aneeza Khairiyah

AU - Rimmer, Janet

AU - Alvarado, Raquel

AU - Sewell, William A.

AU - Tatersall, Jessica

AU - Barham, Henry P.

AU - Kalish, Larry

AU - Harvey, Richard J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. Objective: The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. Methods: A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis. Results: A total of 160 patients (41.89 ± 14.65 years, 36.9% females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08–0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95% confidence interval: 0.84–0.90) with 90% sensitivity and 89% negative predictive value. Conclusion: Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.

AB - Background: Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. Objective: The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. Methods: A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis. Results: A total of 160 patients (41.89 ± 14.65 years, 36.9% females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08–0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95% confidence interval: 0.84–0.90) with 90% sensitivity and 89% negative predictive value. Conclusion: Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.

KW - allergen

KW - allergic rhinitis

KW - asymptomatic

KW - immunoglobulin E

KW - inferior turbinate

KW - local allergic rhinitis

KW - nasal symptoms

KW - receiver operating curve

KW - tissue biopsy

KW - tissue sIgE

UR - http://www.scopus.com/inward/record.url?scp=85060757574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060757574&partnerID=8YFLogxK

U2 - 10.1177/1945892418825224

DO - 10.1177/1945892418825224

M3 - Article

JO - American Journal of Rhinology and Allergy

JF - American Journal of Rhinology and Allergy

SN - 1945-8924

ER -