Tunable microfluidic devices for hydrodynamic fractionation of cells and beads: A review

Jafar Alvankarian, Burhanuddin Yeop Majlis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The adjustable microfluidic devices that have been developed for hydrodynamic-based fractionation of beads and cells are important for fast performance tunability through interaction of mechanical properties of particles in fluid flow and mechanically flexible microstructures. In this review, the research works reported on fabrication and testing of the tunable elastomeric microfluidic devices for applications such as separation, filtration, isolation, and trapping of single or bulk of microbeads or cells are discussed. Such microfluidic systems for rapid performance alteration are classified in two groups of bulk deformation of microdevices using external mechanical forces, and local deformation of microstructures using flexible membrane by pneumatic pressure. The main advantage of membrane-based tunable systems has been addressed to be the high capability of integration with other microdevice components. The stretchable devices based on bulk deformation of microstructures have in common advantage of simplicity in design and fabrication process.

Original languageEnglish
Pages (from-to)29685-29701
Number of pages17
JournalSensors (Switzerland)
Volume15
Issue number11
DOIs
Publication statusPublished - 24 Nov 2015

Fingerprint

Lab-On-A-Chip Devices
Cell Fractionation
microfluidic devices
Hydrodynamics
Fractionation
Microfluidics
fractionation
beads
hydrodynamics
microstructure
Microstructure
Membranes
cells
Microspheres
membranes
Fabrication
fabrication
pneumatics
Pressure
Equipment and Supplies

Keywords

  • Cells
  • Fractionation
  • Hydrodynamic
  • Mechanical
  • Microbeads
  • Microfluidic
  • Tunable

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Analytical Chemistry
  • Biochemistry

Cite this

Tunable microfluidic devices for hydrodynamic fractionation of cells and beads : A review. / Alvankarian, Jafar; Yeop Majlis, Burhanuddin.

In: Sensors (Switzerland), Vol. 15, No. 11, 24.11.2015, p. 29685-29701.

Research output: Contribution to journalArticle

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