Try to Remember

Interplay between Memory and Substance Use Disorder

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insights that suggest memories associated with substance use disorder may follow unique neurobiological pathways that render them more accessible to pharmacological intervention. In parallel to this, research in neurochemistry has identified several potential candidate molecules that could influence the formation and maintenance of long-term memory. Drugs that target these molecules (blebbistatin, isradipine and zeta inhibitory peptide) have shown promise at the preclinical stage. In this review, we shall provide an overview of the evolving understanding on the biochemical mechanisms involved in memory formation and expound on the premise that substance use disorder is a learning disorder.

Original languageEnglish
Pages (from-to)158-165
Number of pages8
JournalCurrent Drug Targets
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Substance-Related Disorders
Data storage equipment
Isradipine
Neurochemistry
Neuronal Plasticity
Long-Term Memory
Learning Disorders
Molecules
Cues
Consensus
Pharmacology
Plasticity
Recurrence
Peptides
Research
Pharmaceutical Preparations

Keywords

  • Addiction
  • blebbistatin
  • cue
  • isradipine
  • memory
  • PKM zeta
  • relapse.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Try to Remember : Interplay between Memory and Substance Use Disorder. / Pakri Mohamed, Rashidi Mohamed; Kumar, Jaya; Yap, Sze Wei; Naina Mohamed, Isa; Sidi, Hatta; Adam, Raja Lope; Das, Srijit.

In: Current Drug Targets, Vol. 20, No. 2, 01.01.2019, p. 158-165.

Research output: Contribution to journalArticle

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