Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia

Research output: Contribution to journalArticle

Abstract

We reported a young patient with myelodysplastic syndrome (MDS) with eosinophilia, in which her chromosomal analysis revealed the presence of trisomy X and a marker chromosome at chromosome 11. The technique used to detect the chromosomal abnormalities is a multicoloured -fluorescent in situ hybridization technique (M-FISH). Our observation suggested that these underlying chromosomal abnormalities were probably responsible for her development of MDS with eosinophilia. Myelodysplastic syndrome (MDS) is a condition whereby there is ineffective production of haematopoietic stem cells and poor quality of cells produced. The cause can either be a primary bone marrow problem, de novo or therapy related. Most MDS cases are secondary rather than primary. Many chromosomal abnormalities have been found in cases of myelodysplastic syndrome. We described a case of MDS with eosinophilia in association with presence of trisomy X and a marker chromosome in chromosome 11.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalMalaysian Journal of Medicine and Health Sciences
Volume8
Issue number2
Publication statusPublished - Jun 2012

Fingerprint

Myelodysplastic Syndromes
Eosinophilia
Chromosome Aberrations
Chromosomes, Human, Pair 11
Genetic Markers
Hematopoietic Stem Cells
Fluorescence In Situ Hybridization
Triple X syndrome
Bone Marrow
Observation

Keywords

  • Eosinophilia
  • Myelodysplastic syndrome
  • Trisomy X

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia. / Eusni, R. M T; Chooi Fun, Leong; Shuib, Salwati.

In: Malaysian Journal of Medicine and Health Sciences, Vol. 8, No. 2, 06.2012, p. 65-67.

Research output: Contribution to journalArticle

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