Treatment of preeclampsia with hydroxychloroquine

a review

Rahana Abd Rahman, Philip DeKoninck, Padma Murthi, Euan M. Wallace

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

In this review, we discuss the potential use of antimalarial drugs as an adjuvant therapy for preeclampsia, focusing on the mechanisms of action of this class of drugs in the context of preeclampsia. In particular, hydroxychloroquine has been shown to have various beneficial effects on patients with systemic lupus erythematosus. There are several pathways targeted by the antimalarial drugs that are similar to the pathophysiology of preeclampsia and hence offering opportunities to develop novel therapies to treat the disease. Given the safety profile of hydroxychloroquine in pregnancy, there is merit in exploring the efficacy of this drug as an adjuvant therapy in women with early onset preeclampsia.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume31
Issue number4
DOIs
Publication statusPublished - 16 Feb 2018

Fingerprint

Hydroxychloroquine
Pre-Eclampsia
Antimalarials
Therapeutics
Adjuvant Chemotherapy
Systemic Lupus Erythematosus
Safety
Pregnancy
Pharmaceutical Preparations

Keywords

  • antimalarial drugs
  • mechanisms of action
  • Preeclampsia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Treatment of preeclampsia with hydroxychloroquine : a review. / Abd Rahman, Rahana; DeKoninck, Philip; Murthi, Padma; Wallace, Euan M.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 31, No. 4, 16.02.2018, p. 525-529.

Research output: Contribution to journalReview article

Abd Rahman, Rahana ; DeKoninck, Philip ; Murthi, Padma ; Wallace, Euan M. / Treatment of preeclampsia with hydroxychloroquine : a review. In: Journal of Maternal-Fetal and Neonatal Medicine. 2018 ; Vol. 31, No. 4. pp. 525-529.
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