Treatment of chronic hepatitis C virus infection with interferon alfa and ribavirin

Sustained response in two patients with transfusion dependent thalassaemia

Hamidah Alias, J. F. Yong, H. I. Zulkifli, A. Rahman A. Jamal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We describe two cases of transfusion dependent thalassaemics with chronic hepatitis C virus infection whom were treated successfully with interferon and ribavirin, following failure of response or relapse after an initial response to interferon monotherapy. They had sustained virological response for more than twelve months after completing therapy. Transfusion requirements were significantly increased during the combination therapy, probably due to ribavirin-induced haemolysis. Serum ferritin level decreased significantly during the treatment. Combination therapy with interferon alfa and ribavirin may be a feasible treatment option for some nonresponders to prior interferon monotherapy.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalMedical Journal of Malaysia
Volume57
Issue number3
Publication statusPublished - Sep 2002

Fingerprint

Thalassemia
Ribavirin
Chronic Hepatitis C
Virus Diseases
Interferon-alpha
Hepacivirus
Interferons
Therapeutics
Ferritins
Hemolysis
Recurrence
Serum

Keywords

  • Blood transfusion
  • Hepatitis C virus
  • Interferon
  • Ribavirin
  • Thalassaemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "We describe two cases of transfusion dependent thalassaemics with chronic hepatitis C virus infection whom were treated successfully with interferon and ribavirin, following failure of response or relapse after an initial response to interferon monotherapy. They had sustained virological response for more than twelve months after completing therapy. Transfusion requirements were significantly increased during the combination therapy, probably due to ribavirin-induced haemolysis. Serum ferritin level decreased significantly during the treatment. Combination therapy with interferon alfa and ribavirin may be a feasible treatment option for some nonresponders to prior interferon monotherapy.",
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AU - Alias, Hamidah

AU - Yong, J. F.

AU - Zulkifli, H. I.

AU - A. Jamal, A. Rahman

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AB - We describe two cases of transfusion dependent thalassaemics with chronic hepatitis C virus infection whom were treated successfully with interferon and ribavirin, following failure of response or relapse after an initial response to interferon monotherapy. They had sustained virological response for more than twelve months after completing therapy. Transfusion requirements were significantly increased during the combination therapy, probably due to ribavirin-induced haemolysis. Serum ferritin level decreased significantly during the treatment. Combination therapy with interferon alfa and ribavirin may be a feasible treatment option for some nonresponders to prior interferon monotherapy.

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KW - Hepatitis C virus

KW - Interferon

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