Transmembrane adaptor molecules: A new category of lymphoid-cell markers

Sara Tedoldi, Jennifer C. Paterson, Martin Leo Hansmann, Yasodha Natkunam, Thomas Rüdiger, Pavla Angelisova, Ming Q. Du, Helen Roberton, Giovanna Roncador, Lydia Sanchez, Michela Pozzobon, Noraidah Masir, Richard Barry, Stefano Pileri, David Y. Mason, Teresa Marafioti, Václav Horejsí

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Transmembrane adaptor proteins (of which 7 have been identified so far) are involved in receptor signaling in immune cells. They have only a short extracellular region, with most of the molecule comprising a substantial intracytoplasmic region carrying multiple tyrosine residues that can be phosphorylated by Src- or Syk-family kinases. In this paper, we report an immunohistologic study of 6 of these molecules in normal and neoplastic human tissue sections and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT). Their expression in neoplastic lymphoid cells broadly reflects that of normal lymphoid tissue, including the positivity of plasma cells and myeloma/plasmacytoma for LIME, NTAL, PAG, and SIT. However, this study also revealed some reactions that may be of diagnostic/prognostic value. For example, lymphocytic lymphoma and mantle-cell lymphoma showed similar profiles but differed clearly from follicle-center lymphoma, whereas PAG tended to be selectively expressed in germinal center-derived subsets of diffuse large B-cell lymphoma. These molecules represent a potentially important addition to the panel of immunophenotypic markers detectable in routine biopsies that can be used in hematopathologic studies.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalBlood
Volume107
Issue number1
DOIs
Publication statusPublished - 1 Jan 2006

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Cells
Lymphocytes
Mantle-Cell Lymphoma
Molecules
Germinal Center
Plasmacytoma
Lymphoma, Large B-Cell, Diffuse
Lymphoid Tissue
B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
Tissue
Tyrosine
Lymphoma
B-Lymphocytes
T-cells
Biopsy
T-Lymphocytes
Phosphotransferases
Plasmas
Proteins

ASJC Scopus subject areas

  • Hematology

Cite this

Tedoldi, S., Paterson, J. C., Hansmann, M. L., Natkunam, Y., Rüdiger, T., Angelisova, P., ... Horejsí, V. (2006). Transmembrane adaptor molecules: A new category of lymphoid-cell markers. Blood, 107(1), 213-221. https://doi.org/10.1182/blood-2005-06-2273

Transmembrane adaptor molecules : A new category of lymphoid-cell markers. / Tedoldi, Sara; Paterson, Jennifer C.; Hansmann, Martin Leo; Natkunam, Yasodha; Rüdiger, Thomas; Angelisova, Pavla; Du, Ming Q.; Roberton, Helen; Roncador, Giovanna; Sanchez, Lydia; Pozzobon, Michela; Masir, Noraidah; Barry, Richard; Pileri, Stefano; Mason, David Y.; Marafioti, Teresa; Horejsí, Václav.

In: Blood, Vol. 107, No. 1, 01.01.2006, p. 213-221.

Research output: Contribution to journalArticle

Tedoldi, S, Paterson, JC, Hansmann, ML, Natkunam, Y, Rüdiger, T, Angelisova, P, Du, MQ, Roberton, H, Roncador, G, Sanchez, L, Pozzobon, M, Masir, N, Barry, R, Pileri, S, Mason, DY, Marafioti, T & Horejsí, V 2006, 'Transmembrane adaptor molecules: A new category of lymphoid-cell markers', Blood, vol. 107, no. 1, pp. 213-221. https://doi.org/10.1182/blood-2005-06-2273
Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rüdiger T, Angelisova P et al. Transmembrane adaptor molecules: A new category of lymphoid-cell markers. Blood. 2006 Jan 1;107(1):213-221. https://doi.org/10.1182/blood-2005-06-2273
Tedoldi, Sara ; Paterson, Jennifer C. ; Hansmann, Martin Leo ; Natkunam, Yasodha ; Rüdiger, Thomas ; Angelisova, Pavla ; Du, Ming Q. ; Roberton, Helen ; Roncador, Giovanna ; Sanchez, Lydia ; Pozzobon, Michela ; Masir, Noraidah ; Barry, Richard ; Pileri, Stefano ; Mason, David Y. ; Marafioti, Teresa ; Horejsí, Václav. / Transmembrane adaptor molecules : A new category of lymphoid-cell markers. In: Blood. 2006 ; Vol. 107, No. 1. pp. 213-221.
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