Transient abnormal myelopoeisis in newborns with Down syndrome.

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Abstract

Transient abnormal myelopoeisis (TAM) is a haematological phenomenon commonly seen in newborns with Down syndrome. Although the majority show spontaneous resolution, this condition should not be dismissed too readily as there have been associated fatalities. Furthermore, even for those who do show spontaneous resolution, a significant percentage will develop acute megakaryoblastic leukaemia within the next few years of life. We report a series of four patients with TAM who presented with hepatosplenomegaly and leucocytosis detected on preliminary investigations.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalThe Malaysian journal of pathology
Volume29
Issue number2
Publication statusPublished - Dec 2007

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Leukemia, Megakaryoblastic, Acute
Leukocytosis
Down Syndrome
Newborn Infant

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{5578db65fe2149339757f166268360ab,
title = "Transient abnormal myelopoeisis in newborns with Down syndrome.",
abstract = "Transient abnormal myelopoeisis (TAM) is a haematological phenomenon commonly seen in newborns with Down syndrome. Although the majority show spontaneous resolution, this condition should not be dismissed too readily as there have been associated fatalities. Furthermore, even for those who do show spontaneous resolution, a significant percentage will develop acute megakaryoblastic leukaemia within the next few years of life. We report a series of four patients with TAM who presented with hepatosplenomegaly and leucocytosis detected on preliminary investigations.",
author = "{Abdul Latiff}, Zarina and Hamidah Alias and Yong, {S. C.} and Rohana Jaafar and Hussin, {Noor Hamidah} and {Raja Sabudin}, {Raja Zahratul Azma} and Boo, {N. Y.} and {A. Jamal}, {A. Rahman}",
year = "2007",
month = "12",
language = "English",
volume = "29",
pages = "107--111",
journal = "Malaysian Journal of Pathology",
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publisher = "Malaysian Society of Pathologists",
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T1 - Transient abnormal myelopoeisis in newborns with Down syndrome.

AU - Abdul Latiff, Zarina

AU - Alias, Hamidah

AU - Yong, S. C.

AU - Jaafar, Rohana

AU - Hussin, Noor Hamidah

AU - Raja Sabudin, Raja Zahratul Azma

AU - Boo, N. Y.

AU - A. Jamal, A. Rahman

PY - 2007/12

Y1 - 2007/12

N2 - Transient abnormal myelopoeisis (TAM) is a haematological phenomenon commonly seen in newborns with Down syndrome. Although the majority show spontaneous resolution, this condition should not be dismissed too readily as there have been associated fatalities. Furthermore, even for those who do show spontaneous resolution, a significant percentage will develop acute megakaryoblastic leukaemia within the next few years of life. We report a series of four patients with TAM who presented with hepatosplenomegaly and leucocytosis detected on preliminary investigations.

AB - Transient abnormal myelopoeisis (TAM) is a haematological phenomenon commonly seen in newborns with Down syndrome. Although the majority show spontaneous resolution, this condition should not be dismissed too readily as there have been associated fatalities. Furthermore, even for those who do show spontaneous resolution, a significant percentage will develop acute megakaryoblastic leukaemia within the next few years of life. We report a series of four patients with TAM who presented with hepatosplenomegaly and leucocytosis detected on preliminary investigations.

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M3 - Article

VL - 29

SP - 107

EP - 111

JO - Malaysian Journal of Pathology

JF - Malaysian Journal of Pathology

SN - 0126-8635

IS - 2

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