Transforming growth factor β and severe asthma: A perfect storm

Mazen Al-Alawi, Hassan Tidi Maharani, Sanjay H. Chotirmall

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to effective future asthma treatments. Transforming growth factor β (TGF-β) is a major mediator involved in pro-inflammatory responses and fibrotic tissue remodeling within the asthmatic lung. Its role however, as a therapeutic target remains controversial. The aim of this review is to highlight its role in severe asthma including interactions with adaptive T-helper cells, cytokines and differentiation through regulatory T-cells. Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma. We highlight TGF-β1 as a potential future therapeutic target in severe asthma including its importance in identifying emerging clinical phenotypes in asthmatic subjects who may be suitable for individualized therapy through TGF-β modulation.

Original languageEnglish
Pages (from-to)1409-1423
Number of pages15
JournalRespiratory Medicine
Volume108
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014
Externally publishedYes

Fingerprint

Transforming Growth Factors
Asthma
Genetic Polymorphisms
Regulatory T-Lymphocytes
Airway Obstruction
Eosinophils
Cell Differentiation
Therapeutics
Biomarkers
Cytokines
Phenotype
Lung
Genes

Keywords

  • Asthma
  • Eosinophil
  • Target
  • TGF-β
  • Therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Al-Alawi, M., Tidi Maharani, H., & Chotirmall, S. H. (2014). Transforming growth factor β and severe asthma: A perfect storm. Respiratory Medicine, 108(10), 1409-1423. https://doi.org/10.1016/j.rmed.2014.08.008

Transforming growth factor β and severe asthma : A perfect storm. / Al-Alawi, Mazen; Tidi Maharani, Hassan; Chotirmall, Sanjay H.

In: Respiratory Medicine, Vol. 108, No. 10, 01.10.2014, p. 1409-1423.

Research output: Contribution to journalReview article

Al-Alawi, M, Tidi Maharani, H & Chotirmall, SH 2014, 'Transforming growth factor β and severe asthma: A perfect storm', Respiratory Medicine, vol. 108, no. 10, pp. 1409-1423. https://doi.org/10.1016/j.rmed.2014.08.008
Al-Alawi, Mazen ; Tidi Maharani, Hassan ; Chotirmall, Sanjay H. / Transforming growth factor β and severe asthma : A perfect storm. In: Respiratory Medicine. 2014 ; Vol. 108, No. 10. pp. 1409-1423.
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