Toxicological evaluation of dried kacangma herb (Leonurus sibiricus) in rats

Chua Hun Pin, Aminah Abdullah, M. Murugaiyah

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Kacangma (Leonurus sibiricus L.) is a popular traditional herb that has been consumed for decades by the people of Sarawak as a herbal medicine or culinary ingredient. The toxicity of dried kacangma herb on Sprague Dawley male and female rats was evaluated through 90-day sub-chronic studies. The rats were fed kacangma at the rate of 0.5 (low dose), 5 (medium dose) and 25 (high dose) g/kg body weight. The control groups of rats received only the commercial rat pellet. Minor treatment-related effects were observed for body weights, organ weights and the lipid profile parameters and these did not appear to be of toxicological significance. In the sub-chronic toxicity studies, some indications of renal and liver toxicity were evident in the medium and high dose groups when plasma creatinine and liver enzymes were found to be higher when compared with the control and the low dose groups. The hematology study reveals statistically significant mild anemia in rats from the medium and high dose groups as indicated by decreases in hemoglobin, red blood cell count and packed cell volume (hematocrit value). Administration of kacangma herb at medium and high dose was also found to cause adverse effects in histopathological structure of the liver and kidney of both male and female rats. However, low dose group showed no significant differences compared to the control. Therefore, it is considered safe and less chance of developing toxicity if the herb is consumed at the dose of 0.5 g/kg body weight as observed throughout the 90 days period of sub-chronic study.

Original languageEnglish
Pages (from-to)499-509
Number of pages11
JournalSains Malaysiana
Volume38
Issue number4
Publication statusPublished - Aug 2009

Fingerprint

Leonurus
Toxicology
Body Weight
Liver
Kidney
Erythrocyte Count
Organ Size
Herbal Medicine
Malaysia
Hematology
Cell Size
Hematocrit
Anemia
Creatinine
Hemoglobins
Lipids
Control Groups
Enzymes

Keywords

  • Hematology
  • Histopathology
  • Leonurus sibiricus
  • Sprague Dawley rats
  • Toxicity evaluation

ASJC Scopus subject areas

  • General

Cite this

Pin, C. H., Abdullah, A., & Murugaiyah, M. (2009). Toxicological evaluation of dried kacangma herb (Leonurus sibiricus) in rats. Sains Malaysiana, 38(4), 499-509.

Toxicological evaluation of dried kacangma herb (Leonurus sibiricus) in rats. / Pin, Chua Hun; Abdullah, Aminah; Murugaiyah, M.

In: Sains Malaysiana, Vol. 38, No. 4, 08.2009, p. 499-509.

Research output: Contribution to journalArticle

Pin, CH, Abdullah, A & Murugaiyah, M 2009, 'Toxicological evaluation of dried kacangma herb (Leonurus sibiricus) in rats', Sains Malaysiana, vol. 38, no. 4, pp. 499-509.
Pin, Chua Hun ; Abdullah, Aminah ; Murugaiyah, M. / Toxicological evaluation of dried kacangma herb (Leonurus sibiricus) in rats. In: Sains Malaysiana. 2009 ; Vol. 38, No. 4. pp. 499-509.
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