Toxicity test of xanthone from mangosteen on zebrafish embryos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Xanthone is a chemical compound identified in mangosteen pericarp. A previous study showed that xanthone has anti-proliferating effect on cancer cells. In this study we investigate the toxicity level of xanthone in zebrafish embryo to for future reference on other animal model. We employed Fish Embryo Toxicity (FET) assay to determine the toxicity level of different concentrations of xanthone. Embryos were observed at 24, 48 and 72 hours post fertilization (hpf) under microscope at 4× magnification. The extract showed toxicity effect on embryo at concentrations of 250, 125 and 62.5 μg/mL. Concentrations at 15.63, 7.81 and 3.91 μg / mL of xanthone did not harm the embryos and showed 100% of survival.

Original languageEnglish
Title of host publication2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1784
ISBN (Electronic)9780735414464
DOIs
Publication statusPublished - 17 Nov 2016
Event2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016 - Selangor, Malaysia
Duration: 13 Apr 201614 Apr 2016

Other

Other2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016
CountryMalaysia
CitySelangor
Period13/4/1614/4/16

Fingerprint

embryos
toxicity
fertilization
chemical compounds
animal models
fishes
magnification
cancer
microscopes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Noordin, M. A. M., Mat Noor, M., Wan Kamaruddin, W. M. A., Mat Lazim, M. A. S., & Sa`Ariwijaya, M. S. F. (2016). Toxicity test of xanthone from mangosteen on zebrafish embryos. In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium (Vol. 1784). [020014] American Institute of Physics Inc.. https://doi.org/10.1063/1.4966724

Toxicity test of xanthone from mangosteen on zebrafish embryos. / Noordin, Muhammad Akram Mohd; Mat Noor, Mahanem; Wan Kamaruddin, Wan Mohd Aizat; Mat Lazim, Mohamad Azwani Shah; Sa`Ariwijaya, Mohd Shazrul Fazry.

2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016. 020014.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noordin, MAM, Mat Noor, M, Wan Kamaruddin, WMA, Mat Lazim, MAS & Sa`Ariwijaya, MSF 2016, Toxicity test of xanthone from mangosteen on zebrafish embryos. in 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. vol. 1784, 020014, American Institute of Physics Inc., 2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016, Selangor, Malaysia, 13/4/16. https://doi.org/10.1063/1.4966724
Noordin MAM, Mat Noor M, Wan Kamaruddin WMA, Mat Lazim MAS, Sa`Ariwijaya MSF. Toxicity test of xanthone from mangosteen on zebrafish embryos. In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784. American Institute of Physics Inc. 2016. 020014 https://doi.org/10.1063/1.4966724
Noordin, Muhammad Akram Mohd ; Mat Noor, Mahanem ; Wan Kamaruddin, Wan Mohd Aizat ; Mat Lazim, Mohamad Azwani Shah ; Sa`Ariwijaya, Mohd Shazrul Fazry. / Toxicity test of xanthone from mangosteen on zebrafish embryos. 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016.
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