Toxic effect of gestational exposure to nonylphenol on F1 male rats

Xu Jie, Wang Yang, Yu Jie, Jamal Hisham Hashim, Xiao Yun Liu, Qi Yuan Fan, Li Yan

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    OBJECTIVE: The purpose of this study was to examine whether gestational exposure to major environmental endocrine-disrupting chemicals, nonylphenol (NP), would lead to nerve behavioral and learning and memory capacity alterations in the male offspring of rats, and reproductive development alterations in the male offspring of rats. METHODS: Dams were gavaged with NP at a dose level of 50-mg/kg/day, 100-mg/kg/day or 200-mg/kg/day daily from gestational day 9 to 15, and at a dose level of 40-mg/kg/day, 80-mg/kg/day or 200-mg/kg/day daily from gestational day 14 to 19 (transplacental exposures). RESULTS: Exposure to 200-mg/kg/day NP produced a significant decrease in learning and memory functions in offspring rats (P<0.05) in Morris water maze task, as demonstrated by the increased escape latency and number of error. In Step-down Avoidance Test, offspring rats exposed to NP spent more reaction time (RT) and presented lower latency to first step-down than the control offspring (P<0.01). In utero exposure to 80 and 200-mg/kg/day NP produced a significant decrease in the number of live pups per litter and ratio of anogenital distance to body length on PND 0 (P<0.05), and also testes and prostate weight, activities of ALP, plasma testosterone concentration, cauda epididymis sperm counts, daily sperm production et al. respectively on PND 90 (P<0.05). Histopathological examination of the brain biopsy illustrates that exposure to NP at high dose induces the presence of abnormal distribution of spermatozoa showed in lumina of the seminiferous tubules, and absence of spermatogenesis and spermiogenesis. CONCLUSION: Gestational exposure to nonylphenol might induce neurotoxic and reproductive toxic effects on F1 male rats.

    Original languageEnglish
    Pages (from-to)418-428
    Number of pages11
    JournalBirth Defects Research Part B - Developmental and Reproductive Toxicology
    Volume89
    Issue number5
    DOIs
    Publication statusPublished - Oct 2010

    Fingerprint

    Poisons
    Rats
    Spermatogenesis
    Maternal-Fetal Exchange
    Learning
    Endocrine Disruptors
    Data storage equipment
    Seminiferous Tubules
    Sperm Count
    Biopsy
    Epididymis
    nonylphenol
    Dams
    Reaction Time
    Testosterone
    Spermatozoa
    Testis
    Prostate
    Brain
    Plasmas

    Keywords

    • Learning and memory capacity
    • Neurobehavioral development
    • Nonylphenol
    • Offspring rats
    • Reproduction development

    ASJC Scopus subject areas

    • Developmental Biology
    • Embryology
    • Toxicology
    • Health, Toxicology and Mutagenesis

    Cite this

    Toxic effect of gestational exposure to nonylphenol on F1 male rats. / Jie, Xu; Yang, Wang; Jie, Yu; Hashim, Jamal Hisham; Liu, Xiao Yun; Fan, Qi Yuan; Yan, Li.

    In: Birth Defects Research Part B - Developmental and Reproductive Toxicology, Vol. 89, No. 5, 10.2010, p. 418-428.

    Research output: Contribution to journalArticle

    Jie, Xu ; Yang, Wang ; Jie, Yu ; Hashim, Jamal Hisham ; Liu, Xiao Yun ; Fan, Qi Yuan ; Yan, Li. / Toxic effect of gestational exposure to nonylphenol on F1 male rats. In: Birth Defects Research Part B - Developmental and Reproductive Toxicology. 2010 ; Vol. 89, No. 5. pp. 418-428.
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    abstract = "OBJECTIVE: The purpose of this study was to examine whether gestational exposure to major environmental endocrine-disrupting chemicals, nonylphenol (NP), would lead to nerve behavioral and learning and memory capacity alterations in the male offspring of rats, and reproductive development alterations in the male offspring of rats. METHODS: Dams were gavaged with NP at a dose level of 50-mg/kg/day, 100-mg/kg/day or 200-mg/kg/day daily from gestational day 9 to 15, and at a dose level of 40-mg/kg/day, 80-mg/kg/day or 200-mg/kg/day daily from gestational day 14 to 19 (transplacental exposures). RESULTS: Exposure to 200-mg/kg/day NP produced a significant decrease in learning and memory functions in offspring rats (P<0.05) in Morris water maze task, as demonstrated by the increased escape latency and number of error. In Step-down Avoidance Test, offspring rats exposed to NP spent more reaction time (RT) and presented lower latency to first step-down than the control offspring (P<0.01). In utero exposure to 80 and 200-mg/kg/day NP produced a significant decrease in the number of live pups per litter and ratio of anogenital distance to body length on PND 0 (P<0.05), and also testes and prostate weight, activities of ALP, plasma testosterone concentration, cauda epididymis sperm counts, daily sperm production et al. respectively on PND 90 (P<0.05). Histopathological examination of the brain biopsy illustrates that exposure to NP at high dose induces the presence of abnormal distribution of spermatozoa showed in lumina of the seminiferous tubules, and absence of spermatogenesis and spermiogenesis. CONCLUSION: Gestational exposure to nonylphenol might induce neurotoxic and reproductive toxic effects on F1 male rats.",
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    AU - Hashim, Jamal Hisham

    AU - Liu, Xiao Yun

    AU - Fan, Qi Yuan

    AU - Yan, Li

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