Towards the development of synthetic antibiotics

Designs inspired by natural antimicrobial peptides

Fazren Azmi, Mariusz Skwarczynski, Istvan Toth

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Virtually every living organism produces gene-encoded antimicrobial peptides (AMPs) that provide an immediate defence against pathogen invasion. Many AMPs have been isolated and used as antibiotics that are effective against multidrug-resistant bacteria. Although encouraging, AMPs have such poor drug-like properties that their application for clinical use is restricted. In turn, this has diverted research to the development of synthetic molecules that retain the therapeutic efficacy of AMPs but are endowed with greater biological stability and safety profiles. Most of the synthetic molecules, either based on a peptidic or non-peptidic scaffold, have been designed to mimic the amphiphilic properties of native AMPs, which are widely believed to be the key determinant of their antibacterial activity. In this review, the structural, chemical and biophysical features that govern the biological activities of various synthetic designs are discussed extensively. Recent innovative approaches from the literature that exhibit novel concepts towards the development of new synthetic antibacterial agents, including the engineered delivery platform incorporated with AMP mimetics, are also emphasised.

Original languageEnglish
Pages (from-to)4610-4624
Number of pages15
JournalCurrent Medicinal Chemistry
Volume23
Issue number41
DOIs
Publication statusPublished - 1 Dec 2016

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Anti-Bacterial Agents
Peptides
Molecules
Pathogens
Bioactivity
Scaffolds
Bacteria
Genes
Safety
Research
Pharmaceutical Preparations
Therapeutics

Keywords

  • Amphiphilic properties
  • Antibacterial
  • Antimicrobial peptides
  • Multidrug-resistant bacteria
  • Peptide
  • Peptidomimetics
  • Polymer
  • Synthetic mimics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Towards the development of synthetic antibiotics : Designs inspired by natural antimicrobial peptides. / Azmi, Fazren; Skwarczynski, Mariusz; Toth, Istvan.

In: Current Medicinal Chemistry, Vol. 23, No. 41, 01.12.2016, p. 4610-4624.

Research output: Contribution to journalReview article

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