Topological characterization of a bacterial cellulose-acrylic acid polymeric matrix

N. Halib, Mohd Cairul Iqbal Mohd Amin, Ishak Ahmad, M. Abrami, S. Fiorentino, R. Farra, G. Grassi, F. Musiani, R. Lapasin, M. Grassi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This paper focuses on the micro- and nano-topological organization of a hydrogel, constituted by a mixture of bacterial cellulose and acrylic acid, and intended for biomedical applications. The presence of acrylic acid promotes the formation of two interpenetrated continuous phases: the primary "pores phase" (PP) containing only water and the secondary "polymeric network phase" (PNP) constituted by the polymeric network swollen by the water. Low field Nuclear Magnetic Resonance (LF NMR), rheology, Scanning Electron Microscopy (SEM) and release tests were used to determine the characteristics of the two phases. In particular, we found that this system is a strong hydrogel constituted by 81% (v/v) of PP phase the remaining part being occupied by the PNP phase. Pores diameters span in the range 10-100 μm, the majority of them (85%) falling in the range 30-90 μm. The high PP phase tortuosity indicates that big pores are not directly connected to each other, but their connection is realized by a series of interconnected small pores that rend the drug path tortuous. The PNP is characterized by a polymer volume fraction around 0.73 while mesh size is around 3 nm. The theoretical interpretation of the experimental data coming from the techniques panel adopted, yielded to the micro- and nano-organization of our hydrogel.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalEuropean Journal of Pharmaceutical Sciences
Volume62
DOIs
Publication statusPublished - 1 Oct 2014

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Hydrogel
Cellulose
Water
Rheology
Electron Scanning Microscopy
Polymers
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations
acrylic acid

Keywords

  • Drug release
  • Low field NMR
  • Mesh-size
  • Porous gels
  • Rheology

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Topological characterization of a bacterial cellulose-acrylic acid polymeric matrix. / Halib, N.; Mohd Amin, Mohd Cairul Iqbal; Ahmad, Ishak; Abrami, M.; Fiorentino, S.; Farra, R.; Grassi, G.; Musiani, F.; Lapasin, R.; Grassi, M.

In: European Journal of Pharmaceutical Sciences, Vol. 62, 01.10.2014, p. 326-333.

Research output: Contribution to journalArticle

Halib, N. ; Mohd Amin, Mohd Cairul Iqbal ; Ahmad, Ishak ; Abrami, M. ; Fiorentino, S. ; Farra, R. ; Grassi, G. ; Musiani, F. ; Lapasin, R. ; Grassi, M. / Topological characterization of a bacterial cellulose-acrylic acid polymeric matrix. In: European Journal of Pharmaceutical Sciences. 2014 ; Vol. 62. pp. 326-333.
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