Toll-like receptors and cancer, particularly oral squamous cell carcinoma

Alison Mary Rich, Haizal Mohd Hussaini, Venkata P B Parachuru, Gregory J. Seymour

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    It is becoming increasingly apparent that the tumor microenvironment plays an important role in the progression of cancer. The microenvironment may promote tumor cell survival and proliferation or, alternatively may induce tumor cell apoptosis. Toll-like receptors (TLRs) are transmembrane proteins, expressed on immune cells and epithelial cells, that recognize exogenous and endogenous macromolecules. Once activated, they initiate signaling pathways leading to the release of cytokines and chemokines, which recruit immune cells inducing further cytokine production, the production of angiogenic mediators and growth factors, all of which may influence tumor progression. This paper examines the actions of TLRs in carcinogenesis with particular emphasis on their role in oral squamous cell carcinoma.

    Original languageEnglish
    Article number464
    JournalFrontiers in Immunology
    Volume5
    Issue numberSEP
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Toll-Like Receptors
    Mouth Neoplasms
    Squamous Cell Carcinoma
    Neoplasms
    Cytokines
    Tumor Microenvironment
    Angiogenesis Inducing Agents
    Chemokines
    Cell Survival
    Intercellular Signaling Peptides and Proteins
    Carcinogenesis
    Epithelial Cells
    Cell Proliferation
    Apoptosis
    Proteins

    Keywords

    • NF-κB
    • Oral squamous cell carcinoma
    • TLR
    • Toll-like receptors

    ASJC Scopus subject areas

    • Immunology
    • Immunology and Allergy

    Cite this

    Rich, A. M., Hussaini, H. M., Parachuru, V. P. B., & Seymour, G. J. (2014). Toll-like receptors and cancer, particularly oral squamous cell carcinoma. Frontiers in Immunology, 5(SEP), [464]. https://doi.org/10.3389/fimmu.2014.00464

    Toll-like receptors and cancer, particularly oral squamous cell carcinoma. / Rich, Alison Mary; Hussaini, Haizal Mohd; Parachuru, Venkata P B; Seymour, Gregory J.

    In: Frontiers in Immunology, Vol. 5, No. SEP, 464, 2014.

    Research output: Contribution to journalArticle

    Rich, Alison Mary ; Hussaini, Haizal Mohd ; Parachuru, Venkata P B ; Seymour, Gregory J. / Toll-like receptors and cancer, particularly oral squamous cell carcinoma. In: Frontiers in Immunology. 2014 ; Vol. 5, No. SEP.
    @article{dc536a3f8a6c4579ab38f3aafa666fde,
    title = "Toll-like receptors and cancer, particularly oral squamous cell carcinoma",
    abstract = "It is becoming increasingly apparent that the tumor microenvironment plays an important role in the progression of cancer. The microenvironment may promote tumor cell survival and proliferation or, alternatively may induce tumor cell apoptosis. Toll-like receptors (TLRs) are transmembrane proteins, expressed on immune cells and epithelial cells, that recognize exogenous and endogenous macromolecules. Once activated, they initiate signaling pathways leading to the release of cytokines and chemokines, which recruit immune cells inducing further cytokine production, the production of angiogenic mediators and growth factors, all of which may influence tumor progression. This paper examines the actions of TLRs in carcinogenesis with particular emphasis on their role in oral squamous cell carcinoma.",
    keywords = "NF-κB, Oral squamous cell carcinoma, TLR, Toll-like receptors",
    author = "Rich, {Alison Mary} and Hussaini, {Haizal Mohd} and Parachuru, {Venkata P B} and Seymour, {Gregory J.}",
    year = "2014",
    doi = "10.3389/fimmu.2014.00464",
    language = "English",
    volume = "5",
    journal = "Frontiers in Immunology",
    issn = "1664-3224",
    publisher = "Frontiers Media S. A.",
    number = "SEP",

    }

    TY - JOUR

    T1 - Toll-like receptors and cancer, particularly oral squamous cell carcinoma

    AU - Rich, Alison Mary

    AU - Hussaini, Haizal Mohd

    AU - Parachuru, Venkata P B

    AU - Seymour, Gregory J.

    PY - 2014

    Y1 - 2014

    N2 - It is becoming increasingly apparent that the tumor microenvironment plays an important role in the progression of cancer. The microenvironment may promote tumor cell survival and proliferation or, alternatively may induce tumor cell apoptosis. Toll-like receptors (TLRs) are transmembrane proteins, expressed on immune cells and epithelial cells, that recognize exogenous and endogenous macromolecules. Once activated, they initiate signaling pathways leading to the release of cytokines and chemokines, which recruit immune cells inducing further cytokine production, the production of angiogenic mediators and growth factors, all of which may influence tumor progression. This paper examines the actions of TLRs in carcinogenesis with particular emphasis on their role in oral squamous cell carcinoma.

    AB - It is becoming increasingly apparent that the tumor microenvironment plays an important role in the progression of cancer. The microenvironment may promote tumor cell survival and proliferation or, alternatively may induce tumor cell apoptosis. Toll-like receptors (TLRs) are transmembrane proteins, expressed on immune cells and epithelial cells, that recognize exogenous and endogenous macromolecules. Once activated, they initiate signaling pathways leading to the release of cytokines and chemokines, which recruit immune cells inducing further cytokine production, the production of angiogenic mediators and growth factors, all of which may influence tumor progression. This paper examines the actions of TLRs in carcinogenesis with particular emphasis on their role in oral squamous cell carcinoma.

    KW - NF-κB

    KW - Oral squamous cell carcinoma

    KW - TLR

    KW - Toll-like receptors

    UR - http://www.scopus.com/inward/record.url?scp=84919429527&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84919429527&partnerID=8YFLogxK

    U2 - 10.3389/fimmu.2014.00464

    DO - 10.3389/fimmu.2014.00464

    M3 - Article

    AN - SCOPUS:84919429527

    VL - 5

    JO - Frontiers in Immunology

    JF - Frontiers in Immunology

    SN - 1664-3224

    IS - SEP

    M1 - 464

    ER -