Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: A Review

Research output: Contribution to journalArticle

Abstract

Metabolic Syndrome (MetS) involves a cluster of five conditions, i.e. obesity, hyperglycaemia, hypertension, hypertriglyceridemia and low High-Density Lipoprotein (HDL) cholesterol. All components of MetS share an underlying chronic inflammatory aetiology, manifested by increased levels of pro-inflammatory cytokines. The pathogenic role of inflammation in the development of MetS suggested that toll-like receptor (TLR) activation may trigger MetS. This review summarises the supporting evidence on the interactions between MetS and TLR activation, bridged by the elevation of TLR ligands during MetS. The regulatory circuits mediated by TLR activation, which modulates signal propagation, leading to the state of chronic inflammation, are also discussed. Taken together, TLR activation could be the molecular basis in the development of MetS-induced inflammation.

Original languageEnglish
Pages (from-to)1264-1280
Number of pages17
JournalCurrent drug targets
Volume20
Issue number12
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Toll-Like Receptors
Inflammation
Chemical activation
HDL Cholesterol
Hypertriglyceridemia
Cytokines
Ligands
Hyperglycemia
LDL Cholesterol
Networks (circuits)
Obesity
Hypertension

Keywords

  • Cytokine
  • free fatty acids
  • heat shock protein
  • interferon
  • interleukin
  • tumour necrosis factor.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation : A Review. / Wong, Sok Kuan; Kok Yong, Chin; Soelaiman, Ima Nirwana.

In: Current drug targets, Vol. 20, No. 12, 01.01.2019, p. 1264-1280.

Research output: Contribution to journalArticle

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