Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma

L. K. Ng, A. M. Rich, H. M. Hussaini, W. M. Thomson, A. L. Fisher, L. S. Horne, G. J. Seymour

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: The aim of this study was to investigate the expression of toll-like receptor 2 (TLR2) on cells associated with oral squamous cell carcinoma, epithelial dysplasia and irritative hyperplasia, using immunohistochemistry. Results: More immune cells expressed TLR2 in carcinoma and dysplasia than in hyperplasia (P<0.001). No hyperplastic samples showed positive TLR2 staining on keratinocytes, whereas keratinocytes in 64% of cases of carcinoma and 74% of cases of dysplasia were TLR2 positive. Conclusion: Positive TLR2 expression in the microenvironment suggests activation of immune surveillance against the altered epithelium, whereas TLR2 expression by malignant keratinocytes may be indicative of resistance to apoptosis as a pro-survival mechanism.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalBritish Journal of Cancer
Volume104
Issue number3
DOIs
Publication statusPublished - 1 Feb 2011
Externally publishedYes

Fingerprint

Toll-Like Receptor 2
Squamous Cell Carcinoma
Keratinocytes
Hyperplasia
Carcinoma
Epithelium
Immunohistochemistry
Apoptosis
Staining and Labeling

Keywords

  • dysplasia
  • hyperplasia
  • oral squamous cell carcinoma
  • toll-like receptor 2

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ng, L. K., Rich, A. M., Hussaini, H. M., Thomson, W. M., Fisher, A. L., Horne, L. S., & Seymour, G. J. (2011). Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. British Journal of Cancer, 104(3), 460-463. https://doi.org/10.1038/sj.bjc.6606057

Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. / Ng, L. K.; Rich, A. M.; Hussaini, H. M.; Thomson, W. M.; Fisher, A. L.; Horne, L. S.; Seymour, G. J.

In: British Journal of Cancer, Vol. 104, No. 3, 01.02.2011, p. 460-463.

Research output: Contribution to journalArticle

Ng, LK, Rich, AM, Hussaini, HM, Thomson, WM, Fisher, AL, Horne, LS & Seymour, GJ 2011, 'Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma', British Journal of Cancer, vol. 104, no. 3, pp. 460-463. https://doi.org/10.1038/sj.bjc.6606057
Ng, L. K. ; Rich, A. M. ; Hussaini, H. M. ; Thomson, W. M. ; Fisher, A. L. ; Horne, L. S. ; Seymour, G. J. / Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. In: British Journal of Cancer. 2011 ; Vol. 104, No. 3. pp. 460-463.
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