Tocotrienols for bone health

a translational approach

Chwan Li Shen, Annika Klein, Chin Kok Yong, Huanbiao Mo, Peihsuan Tsai, Rong Sen Yang, Ming Chien Chyu, Ima Nirwana Soelaiman

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality. The beneficial effects of tocotrienols on bone health appear to be mediated via antioxidant/anti-inflammatory pathways and/or 3-hydroxy-3-methylglutaryl coenzyme A mechanisms. We discuss (1) an overview of the prevalence and etiology of osteoporosis, (2) types of vitamin E (tocopherols versus tocotrienols), (3) findings of tocotrienols and bone health from published in vitro and animal studies, (4) possible mechanisms involved in bone protection, and (5) challenges and future direction for research.

Original languageEnglish
Pages (from-to)150-165
Number of pages16
JournalAnnals of the New York Academy of Sciences
Volume1401
Issue number1
DOIs
Publication statusPublished - 1 Aug 2017

Fingerprint

Tocotrienols
Bone
Health
Bone and Bones
Osteoporosis
Vitamin E
Tocopherols
Animals
Bone Diseases
Coenzymes
Insurance Benefits
Life Expectancy
Bone Density
Anti-Inflammatory Agents
Eating
Antioxidants
Minerals
Deterioration

Keywords

  • animals
  • bone health
  • cells
  • osteoporosis
  • tocotrienols
  • vitamin E

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Tocotrienols for bone health : a translational approach. / Shen, Chwan Li; Klein, Annika; Kok Yong, Chin; Mo, Huanbiao; Tsai, Peihsuan; Yang, Rong Sen; Chyu, Ming Chien; Soelaiman, Ima Nirwana.

In: Annals of the New York Academy of Sciences, Vol. 1401, No. 1, 01.08.2017, p. 150-165.

Research output: Contribution to journalReview article

Shen, Chwan Li ; Klein, Annika ; Kok Yong, Chin ; Mo, Huanbiao ; Tsai, Peihsuan ; Yang, Rong Sen ; Chyu, Ming Chien ; Soelaiman, Ima Nirwana. / Tocotrienols for bone health : a translational approach. In: Annals of the New York Academy of Sciences. 2017 ; Vol. 1401, No. 1. pp. 150-165.
@article{1cd2a0892b7c4ee4b6b78ee274410406,
title = "Tocotrienols for bone health: a translational approach",
abstract = "Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality. The beneficial effects of tocotrienols on bone health appear to be mediated via antioxidant/anti-inflammatory pathways and/or 3-hydroxy-3-methylglutaryl coenzyme A mechanisms. We discuss (1) an overview of the prevalence and etiology of osteoporosis, (2) types of vitamin E (tocopherols versus tocotrienols), (3) findings of tocotrienols and bone health from published in vitro and animal studies, (4) possible mechanisms involved in bone protection, and (5) challenges and future direction for research.",
keywords = "animals, bone health, cells, osteoporosis, tocotrienols, vitamin E",
author = "Shen, {Chwan Li} and Annika Klein and {Kok Yong}, Chin and Huanbiao Mo and Peihsuan Tsai and Yang, {Rong Sen} and Chyu, {Ming Chien} and Soelaiman, {Ima Nirwana}",
year = "2017",
month = "8",
day = "1",
doi = "10.1111/nyas.13449",
language = "English",
volume = "1401",
pages = "150--165",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Tocotrienols for bone health

T2 - a translational approach

AU - Shen, Chwan Li

AU - Klein, Annika

AU - Kok Yong, Chin

AU - Mo, Huanbiao

AU - Tsai, Peihsuan

AU - Yang, Rong Sen

AU - Chyu, Ming Chien

AU - Soelaiman, Ima Nirwana

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality. The beneficial effects of tocotrienols on bone health appear to be mediated via antioxidant/anti-inflammatory pathways and/or 3-hydroxy-3-methylglutaryl coenzyme A mechanisms. We discuss (1) an overview of the prevalence and etiology of osteoporosis, (2) types of vitamin E (tocopherols versus tocotrienols), (3) findings of tocotrienols and bone health from published in vitro and animal studies, (4) possible mechanisms involved in bone protection, and (5) challenges and future direction for research.

AB - Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality. The beneficial effects of tocotrienols on bone health appear to be mediated via antioxidant/anti-inflammatory pathways and/or 3-hydroxy-3-methylglutaryl coenzyme A mechanisms. We discuss (1) an overview of the prevalence and etiology of osteoporosis, (2) types of vitamin E (tocopherols versus tocotrienols), (3) findings of tocotrienols and bone health from published in vitro and animal studies, (4) possible mechanisms involved in bone protection, and (5) challenges and future direction for research.

KW - animals

KW - bone health

KW - cells

KW - osteoporosis

KW - tocotrienols

KW - vitamin E

UR - http://www.scopus.com/inward/record.url?scp=85030611683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030611683&partnerID=8YFLogxK

U2 - 10.1111/nyas.13449

DO - 10.1111/nyas.13449

M3 - Review article

VL - 1401

SP - 150

EP - 165

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

IS - 1

ER -