Tocotrienols and bone health

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pathogenesis of osteoporosis is multifactorial. Oxygen-derived free radicals are involved in the formation and activation of osteoclasts (Garrett et al., 1990), leading to an increase in bone resorption and bone loss. Bone histomorphometric studies have shown that ferric nitrilotriacetate (Fe-NTA), an oxidizing agent, increased osteoclast numbers (Ebina et al., 1991) and impaired mineralization (Takeuchi et al., 1997). Osteoporotic women had significantly higher plasma superoxide dismutase (SOD) enzyme activity and higher malondialdehyde (MDA) levels while glutathione peroxidase (GSH-Px) enzyme activity and nitric oxide (NO) levels were similar when compared to non-osteoporotic controls (Ozgocmen et al., 2007). A negative correlation was found between SOD and lumbar bone mineral density (BMD) levels (r = -0.328; p = 0.021). The same trend was observed between NO and lumbar BMD (r = -0.473; p = 0.001) and femoral neck BMD values (r =-0.540; p = 0.000) (Yalin et al., 2005). Low bone mineral density was associated with increased 8-iso-prostaglandin F2α, an oxidative stress biomarker (Basu et al., 2001). Based on the close association between free radicals and osteoporosis, there is reason to believe that antioxidants, notably the tocotrienols, may be effective in the prevention and treatment of osteoporosis. The most easily available source of tocotrienols in Malaysia is from palm oil. Palm cooking oil contains 178.33 ppm a-tocopherol, 188.50 ppm δ-tocotrienol, 260.83 ppm γ-tocotrienol, and 69.83 ppm d-tocotrienol (Siti Khadijah, 2011). Our studies mainly used tocotrienols extracted from palm oil in the form of tocotrienol mixtures as well as the pure γ-isomer. We used the rat as our animal model since previous studies have shown that their bone anatomy, bone remodeling, and response to treatment are similar to humans (Abe et al., 1993, Mosekilde, 1995).

Original languageEnglish
Title of host publicationTocotrienols
Subtitle of host publicationVitamin E beyond Tocopherols, Second Edition
PublisherCRC Press
Pages305-322
Number of pages18
ISBN (Electronic)9781439884430
ISBN (Print)9781439884416
DOIs
Publication statusPublished - 1 Jan 2012

Fingerprint

Tocotrienols
tocotrienols
Bone
bones
Health
Bone and Bones
bone density
Bone Density
osteoporosis
palm oils
Minerals
Osteoporosis
osteoclasts
Osteoclasts
glutathione peroxidase
Palm oil
Superoxide Dismutase
Free Radicals
nitric oxide
Nitric oxide

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)

Cite this

Soelaiman, I. N., Mohamed, N., Shuid, A. N., & Muhammad, N. (2012). Tocotrienols and bone health. In Tocotrienols: Vitamin E beyond Tocopherols, Second Edition (pp. 305-322). CRC Press. https://doi.org/10.1201/b12502

Tocotrienols and bone health. / Soelaiman, Ima Nirwana; Mohamed, Norazlina; Shuid, Ahmad Nazrun; Muhammad, Norliza.

Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press, 2012. p. 305-322.

Research output: Chapter in Book/Report/Conference proceedingChapter

Soelaiman, IN, Mohamed, N, Shuid, AN & Muhammad, N 2012, Tocotrienols and bone health. in Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press, pp. 305-322. https://doi.org/10.1201/b12502
Soelaiman IN, Mohamed N, Shuid AN, Muhammad N. Tocotrienols and bone health. In Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press. 2012. p. 305-322 https://doi.org/10.1201/b12502
Soelaiman, Ima Nirwana ; Mohamed, Norazlina ; Shuid, Ahmad Nazrun ; Muhammad, Norliza. / Tocotrienols and bone health. Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press, 2012. pp. 305-322
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