Tocotrienols and α-tocopherol reduced acute and chronic lung lipid peroxidation induced by paraquat in rats

A. Y. Asmadi, A. Adam, W. Z. Wan Ngah, Norazlina Mohamed, Kamisah Yusof, Nur Azlina Mohd Fahami, Qodriyah Mohd Saad, Ahmad Nazrun Shuid, M. T. Gapor, A. Marzuki

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12 Citations (Scopus)

Abstract

The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalPakistan Journal of Nutrition
Volume4
Issue number2
DOIs
Publication statusPublished - 2005

Fingerprint

Tocotrienols
tocotrienols
Paraquat
Tocopherols
paraquat
tocopherols
Lipid Peroxidation
lipid peroxidation
Malondialdehyde
lungs
Lung
rats
malondialdehyde
Edema
edema
pellets
alpha-Tocopherol
Dietary Supplements
toxicity
Antioxidants

Keywords

  • Lipid peroxidation
  • Lung
  • Paraquat
  • Rats
  • Tocotrienol
  • α-tocopherol

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

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title = "Tocotrienols and α-tocopherol reduced acute and chronic lung lipid peroxidation induced by paraquat in rats",
abstract = "The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.",
keywords = "Lipid peroxidation, Lung, Paraquat, Rats, Tocotrienol, α-tocopherol",
author = "Asmadi, {A. Y.} and A. Adam and {Wan Ngah}, {W. Z.} and Norazlina Mohamed and Kamisah Yusof and {Mohd Fahami}, {Nur Azlina} and {Mohd Saad}, Qodriyah and Shuid, {Ahmad Nazrun} and Gapor, {M. T.} and A. Marzuki",
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T1 - Tocotrienols and α-tocopherol reduced acute and chronic lung lipid peroxidation induced by paraquat in rats

AU - Asmadi, A. Y.

AU - Adam, A.

AU - Wan Ngah, W. Z.

AU - Mohamed, Norazlina

AU - Yusof, Kamisah

AU - Mohd Fahami, Nur Azlina

AU - Mohd Saad, Qodriyah

AU - Shuid, Ahmad Nazrun

AU - Gapor, M. T.

AU - Marzuki, A.

PY - 2005

Y1 - 2005

N2 - The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.

AB - The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.

KW - Lipid peroxidation

KW - Lung

KW - Paraquat

KW - Rats

KW - Tocotrienol

KW - α-tocopherol

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