Tocotrienol supplementation improves late-phase fracture healing compared to alpha-tocopherol in a rat model of postmenopausal osteoporosis: A biomechanical evaluation

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Abstract

This study investigated the effects of -tocopherol and palm oil tocotrienol supplementations on bone fracture healing in postmenopausal osteoporosis rats. 32 female Sprague-Dawley rats were divided into four groups. The first group was sham operated (SO), while the others were ovariectomised. After 2 months, the right femora were fractured under anesthesia and fixed with K-wire. The SO and ovariectomised-control rats (OVXC) were given olive oil (vehicle), while both the alpha-tocopherol (ATF) and tocotrienol-enriched fraction (TEF) groups were given alpha-tocopherol and tocotrienol-enriched fraction, respectively, at the dose of 60mg/kg via oral gavages 6 days per week for 8 weeks. The rats were then euthanized and the femora dissected out for bone biomechanical testing to assess their strength. The callous of the TEF group had significantly higher stress parameter than the SO and OVXC groups. Only the SO group showed significantly higher strain parameter compared to the other treatment groups. The load parameter of the OVXC and ATF groups was significantly lower than the SO group. There was no significant difference in the Youngs modulus between the groups. In conclusion, tocotrienol is better than -tocopherol in improving the biomechanical properties of the fracture callous in postmenopausal osteoporosis rat model.

Original languageEnglish
Article number372878
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012

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Tocotrienols
Postmenopausal Osteoporosis
Fracture Healing
alpha-Tocopherol
Tocopherols
Femur
Elastic Modulus
Bone Fractures
Sprague Dawley Rats
Anesthesia
Bone and Bones
alpha tocotrienol

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

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title = "Tocotrienol supplementation improves late-phase fracture healing compared to alpha-tocopherol in a rat model of postmenopausal osteoporosis: A biomechanical evaluation",
abstract = "This study investigated the effects of -tocopherol and palm oil tocotrienol supplementations on bone fracture healing in postmenopausal osteoporosis rats. 32 female Sprague-Dawley rats were divided into four groups. The first group was sham operated (SO), while the others were ovariectomised. After 2 months, the right femora were fractured under anesthesia and fixed with K-wire. The SO and ovariectomised-control rats (OVXC) were given olive oil (vehicle), while both the alpha-tocopherol (ATF) and tocotrienol-enriched fraction (TEF) groups were given alpha-tocopherol and tocotrienol-enriched fraction, respectively, at the dose of 60mg/kg via oral gavages 6 days per week for 8 weeks. The rats were then euthanized and the femora dissected out for bone biomechanical testing to assess their strength. The callous of the TEF group had significantly higher stress parameter than the SO and OVXC groups. Only the SO group showed significantly higher strain parameter compared to the other treatment groups. The load parameter of the OVXC and ATF groups was significantly lower than the SO group. There was no significant difference in the Youngs modulus between the groups. In conclusion, tocotrienol is better than -tocopherol in improving the biomechanical properties of the fracture callous in postmenopausal osteoporosis rat model.",
author = "Sharlina Mohamad and Shuid, {Ahmad Nazrun} and Mokhtar, {Sabarul Afian} and Shahrum Abdullah and Soelaiman, {Ima Nirwana}",
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