Tocotrienol-Rich Fraction Supplementation Modulates Antioxidant Enzymes Activity and Reduces DNA Damage in APPswe/PS1dE9 Alzheimer's Disease Mouse Model (Suplementasi Fraksi Kaya Tokotrienol Memodulasi Aktiviti Enzim Antioksidan dan Mengurangkan Kerosakan DNA pada APPswe/PS1dE9 Model Mencit Penyakit Alzheimer)

Mohd Hanafi Ahmad Damanhuri, N. I Abdul Rahim, W. N W Nasri, J. K. Tan, Suzana Makpol, M. Mazlan, I. Tooyama, W. Z Wan Ngah

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2 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by deterioration of the brain functions that result in impairment of memory, cognition and behavioural functions. Oxidative stress is well known to be one of the causative factors for AD. Thus this disease is potentially modulated by natural antioxidants such as Vitamin E. The aim of this study was to evaluate the effect of tocotrienol-rich fraction (TRF) supplementation on antioxidant enzymes and DNA damage using APPswe/PS1dE9 transgenic mouse model of AD. Animals were supplemented with TRF (200 mg/kg) or alpha-Tocopherol (αT) (200 mg/kg) for six months starting from nine months old. We found that superoxide dismutase (SOD) activity in AD mouse was decreased by supplementation of TRF and αT as compared with AD control mouse with no significant differences in glutathione peroxidise (GPx) activity in all groups. TRF supplementation significantly increased catalase (CAT) activity. The level of DNA damage of AD mouse shows significant decrease with supplementation of TRF and αT. In conclusion, TRF was able to modulate antioxidant enzymes activity and decreased the level of DNA damage of AD transgenic mouse model.

Original languageEnglish
Pages (from-to)1363-1370
Number of pages8
JournalSains Malaysiana
Volume45
Issue number9
Publication statusPublished - 1 Sep 2016

Fingerprint

Tocotrienols
DNA Damage
Alzheimer Disease
Antioxidants
DNA
Enzymes
Transgenic Mice
alpha-Tocopherol
Vitamin E
Neurodegenerative Diseases
Catalase
Cognition
Superoxide Dismutase
Glutathione
Oxidative Stress
Brain

Keywords

  • Alzheimer's disease
  • Oxidative status
  • Tocotrienol-rich fractio

ASJC Scopus subject areas

  • General

Cite this

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title = "Tocotrienol-Rich Fraction Supplementation Modulates Antioxidant Enzymes Activity and Reduces DNA Damage in APPswe/PS1dE9 Alzheimer's Disease Mouse Model (Suplementasi Fraksi Kaya Tokotrienol Memodulasi Aktiviti Enzim Antioksidan dan Mengurangkan Kerosakan DNA pada APPswe/PS1dE9 Model Mencit Penyakit Alzheimer)",
abstract = "Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by deterioration of the brain functions that result in impairment of memory, cognition and behavioural functions. Oxidative stress is well known to be one of the causative factors for AD. Thus this disease is potentially modulated by natural antioxidants such as Vitamin E. The aim of this study was to evaluate the effect of tocotrienol-rich fraction (TRF) supplementation on antioxidant enzymes and DNA damage using APPswe/PS1dE9 transgenic mouse model of AD. Animals were supplemented with TRF (200 mg/kg) or alpha-Tocopherol (αT) (200 mg/kg) for six months starting from nine months old. We found that superoxide dismutase (SOD) activity in AD mouse was decreased by supplementation of TRF and αT as compared with AD control mouse with no significant differences in glutathione peroxidise (GPx) activity in all groups. TRF supplementation significantly increased catalase (CAT) activity. The level of DNA damage of AD mouse shows significant decrease with supplementation of TRF and αT. In conclusion, TRF was able to modulate antioxidant enzymes activity and decreased the level of DNA damage of AD transgenic mouse model.",
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author = "{Ahmad Damanhuri}, {Mohd Hanafi} and Rahim, {N. I Abdul} and Nasri, {W. N W} and Tan, {J. K.} and Suzana Makpol and M. Mazlan and I. Tooyama and Ngah, {W. Z Wan}",
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T1 - Tocotrienol-Rich Fraction Supplementation Modulates Antioxidant Enzymes Activity and Reduces DNA Damage in APPswe/PS1dE9 Alzheimer's Disease Mouse Model (Suplementasi Fraksi Kaya Tokotrienol Memodulasi Aktiviti Enzim Antioksidan dan Mengurangkan Kerosakan DNA pada APPswe/PS1dE9 Model Mencit Penyakit Alzheimer)

AU - Ahmad Damanhuri, Mohd Hanafi

AU - Rahim, N. I Abdul

AU - Nasri, W. N W

AU - Tan, J. K.

AU - Makpol, Suzana

AU - Mazlan, M.

AU - Tooyama, I.

AU - Ngah, W. Z Wan

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by deterioration of the brain functions that result in impairment of memory, cognition and behavioural functions. Oxidative stress is well known to be one of the causative factors for AD. Thus this disease is potentially modulated by natural antioxidants such as Vitamin E. The aim of this study was to evaluate the effect of tocotrienol-rich fraction (TRF) supplementation on antioxidant enzymes and DNA damage using APPswe/PS1dE9 transgenic mouse model of AD. Animals were supplemented with TRF (200 mg/kg) or alpha-Tocopherol (αT) (200 mg/kg) for six months starting from nine months old. We found that superoxide dismutase (SOD) activity in AD mouse was decreased by supplementation of TRF and αT as compared with AD control mouse with no significant differences in glutathione peroxidise (GPx) activity in all groups. TRF supplementation significantly increased catalase (CAT) activity. The level of DNA damage of AD mouse shows significant decrease with supplementation of TRF and αT. In conclusion, TRF was able to modulate antioxidant enzymes activity and decreased the level of DNA damage of AD transgenic mouse model.

AB - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by deterioration of the brain functions that result in impairment of memory, cognition and behavioural functions. Oxidative stress is well known to be one of the causative factors for AD. Thus this disease is potentially modulated by natural antioxidants such as Vitamin E. The aim of this study was to evaluate the effect of tocotrienol-rich fraction (TRF) supplementation on antioxidant enzymes and DNA damage using APPswe/PS1dE9 transgenic mouse model of AD. Animals were supplemented with TRF (200 mg/kg) or alpha-Tocopherol (αT) (200 mg/kg) for six months starting from nine months old. We found that superoxide dismutase (SOD) activity in AD mouse was decreased by supplementation of TRF and αT as compared with AD control mouse with no significant differences in glutathione peroxidise (GPx) activity in all groups. TRF supplementation significantly increased catalase (CAT) activity. The level of DNA damage of AD mouse shows significant decrease with supplementation of TRF and αT. In conclusion, TRF was able to modulate antioxidant enzymes activity and decreased the level of DNA damage of AD transgenic mouse model.

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