Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model

Wan Nurzulaikha Wan Nasri, Suzana Makpol, Musalmah Mazlan, Ikuo Tooyama, Wan Zurinah Wan Ngah, Mohd Hanafi Ahmad Damanhuri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive abilities. AD is associated with aggregation of amyloid-β (Aβ) deposited in the hippocampal brain region. Our previous work has shown that tocotrienol rich fraction (TRF) supplementation was able to attenuate the blood oxidative status, improve behavior, and reduce fibrillary-Type Aβ deposition in the hippocampus of an AD mouse model. In the present study, we investigate the effect of 6 months of TRF supplementation on transcriptome profile in the hippocampus of APPswe/PS1dE9 double transgenic mice. TRF supplementation can alleviate AD conditions by modulating several important genes in AD. Moreover, TRF supplementation attenuated the affected biological process and pathways that were upregulated in the AD mouse model. Our findings indicate that TRF supplementation can modulate hippocampal gene expression as well as biological processes that can potentially delay the progression of AD.

Original languageEnglish
Pages (from-to)S239-S254
JournalJournal of Alzheimer's Disease
Volume70
Issue numbers1
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Tocotrienols
Alzheimer Disease
Gene Expression
Brain
Biological Phenomena
Hippocampus
Aptitude
Memory Disorders
Transcriptome
Amyloid
Neurodegenerative Diseases
Transgenic Mice

Keywords

  • Alzheimer's disease
  • hippocampus
  • microarray analysis
  • tocotrienol-rich fraction
  • transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model. / Nasri, Wan Nurzulaikha Wan; Makpol, Suzana; Mazlan, Musalmah; Tooyama, Ikuo; Ngah, Wan Zurinah Wan; Ahmad Damanhuri, Mohd Hanafi.

In: Journal of Alzheimer's Disease, Vol. 70, No. s1, 01.01.2019, p. S239-S254.

Research output: Contribution to journalArticle

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